diff --git a/source/opt/inline_pass.cpp b/source/opt/inline_pass.cpp
index f348bbe3..01ed5b88 100644
--- a/source/opt/inline_pass.cpp
+++ b/source/opt/inline_pass.cpp
@@ -629,12 +629,39 @@ bool InlinePass::GenInlineCode(
   return true;
 }
 
-bool InlinePass::IsInlinableFunctionCall(const Instruction* inst) {
+bool InlinePass::IsInlinableFunctionCall(Instruction* inst) {
   if (inst->opcode() != SpvOp::SpvOpFunctionCall) return false;
   const uint32_t calleeFnId =
       inst->GetSingleWordOperand(kSpvFunctionCallFunctionId);
   const auto ci = inlinable_.find(calleeFnId);
-  return ci != inlinable_.cend();
+  if (ci == inlinable_.cend()) {
+    return false;
+  }
+
+  if (funcs_with_opkill_.count(calleeFnId) == 0) {
+    return true;
+  }
+
+  // We cannot inline into a continue construct if the function has an OpKill.
+  auto* cfg_analysis = context()->GetStructuredCFGAnalysis();
+  BasicBlock* bb = context()->get_instr_block(inst);
+  uint32_t loop_header_id = cfg_analysis->ContainingLoop(bb->id());
+  if (loop_header_id == 0) {
+    // Not in a loop, so we can inline.
+    return true;
+  }
+  BasicBlock* loop_header_bb = context()->get_instr_block(loop_header_id);
+  uint32_t loop_continue =
+      loop_header_bb->GetLoopMergeInst()->GetSingleWordOperand(1);
+
+  Function* caller_func = bb->GetParent();
+  DominatorAnalysis* dom = context()->GetDominatorAnalysis(caller_func);
+  if (dom->Dominates(loop_continue, bb->id())) {
+    // The function call is the continue construct and the callee contains an
+    // OpKill.
+    return false;
+  }
+  return true;
 }
 
 void InlinePass::UpdateSucceedingPhis(
@@ -711,6 +738,9 @@ bool InlinePass::IsInlinableFunction(Function* func) {
   // the returns as a branch to the loop's merge block. However, this can only
   // done validly if the return was not in a loop in the original function.
   // Also remember functions with multiple (early) returns.
+
+  // Do not inline functions with an OpKill because they may be inlined into a
+  // continue construct.
   AnalyzeReturns(func);
   if (no_return_in_loop_.find(func->result_id()) == no_return_in_loop_.cend()) {
     return false;
@@ -741,6 +771,13 @@ void InlinePass::InitializeInline() {
     }
     // Compute inlinability
     if (IsInlinableFunction(&fn)) inlinable_.insert(fn.result_id());
+
+    bool has_opkill = !fn.WhileEachInst(
+        [](Instruction* inst) { return inst->opcode() != SpvOpKill; });
+
+    if (has_opkill) {
+      funcs_with_opkill_.insert(fn.result_id());
+    }
   }
 }
 
diff --git a/source/opt/inline_pass.h b/source/opt/inline_pass.h
index ecfe964f..e17dddb6 100644
--- a/source/opt/inline_pass.h
+++ b/source/opt/inline_pass.h
@@ -122,7 +122,7 @@ class InlinePass : public Pass {
                      UptrVectorIterator<BasicBlock> call_block_itr);
 
   // Return true if |inst| is a function call that can be inlined.
-  bool IsInlinableFunctionCall(const Instruction* inst);
+  bool IsInlinableFunctionCall(Instruction* inst);
 
   // Return true if |func| does not have a return that is
   // nested in a structured if, switch or loop.
@@ -159,6 +159,9 @@ class InlinePass : public Pass {
   // Set of ids of functions with no returns in loop
   std::set<uint32_t> no_return_in_loop_;
 
+  // Set of ids of functions with no returns in loop
+  std::unordered_set<uint32_t> funcs_with_opkill_;
+
   // Set of ids of inlinable functions
   std::set<uint32_t> inlinable_;
 
diff --git a/test/opt/inline_test.cpp b/test/opt/inline_test.cpp
index 71708121..fd38e477 100644
--- a/test/opt/inline_test.cpp
+++ b/test/opt/inline_test.cpp
@@ -3112,6 +3112,121 @@ OpFunctionEnd
   SinglePassRunAndCheck<InlineExhaustivePass>(test, test, false, true);
 }
 
+TEST_F(InlineTest, DontInlineFuncWithOpKill) {
+  const std::string test =
+      R"(OpCapability Shader
+%1 = OpExtInstImport "GLSL.std.450"
+OpMemoryModel Logical GLSL450
+OpEntryPoint Fragment %main "main"
+OpExecutionMode %main OriginUpperLeft
+OpSource GLSL 330
+OpName %main "main"
+OpName %kill_ "kill("
+%void = OpTypeVoid
+%3 = OpTypeFunction %void
+%bool = OpTypeBool
+%true = OpConstantTrue %bool
+%main = OpFunction %void None %3
+%5 = OpLabel
+OpBranch %9
+%9 = OpLabel
+OpLoopMerge %11 %12 None
+OpBranch %13
+%13 = OpLabel
+OpBranchConditional %true %10 %11
+%10 = OpLabel
+OpBranch %12
+%12 = OpLabel
+%16 = OpFunctionCall %void %kill_
+OpBranch %9
+%11 = OpLabel
+OpReturn
+OpFunctionEnd
+%kill_ = OpFunction %void None %3
+%7 = OpLabel
+OpKill
+OpFunctionEnd
+)";
+
+  SetAssembleOptions(SPV_TEXT_TO_BINARY_OPTION_PRESERVE_NUMERIC_IDS);
+  SinglePassRunAndCheck<InlineExhaustivePass>(test, test, false, true);
+}
+
+TEST_F(InlineTest, InlineFuncWithOpKill) {
+  const std::string before =
+      R"(OpCapability Shader
+%1 = OpExtInstImport "GLSL.std.450"
+OpMemoryModel Logical GLSL450
+OpEntryPoint Fragment %main "main"
+OpExecutionMode %main OriginUpperLeft
+OpSource GLSL 330
+OpName %main "main"
+OpName %kill_ "kill("
+%void = OpTypeVoid
+%3 = OpTypeFunction %void
+%bool = OpTypeBool
+%true = OpConstantTrue %bool
+%main = OpFunction %void None %3
+%5 = OpLabel
+OpBranch %9
+%9 = OpLabel
+OpLoopMerge %11 %12 None
+OpBranch %13
+%13 = OpLabel
+OpBranchConditional %true %10 %11
+%10 = OpLabel
+%16 = OpFunctionCall %void %kill_
+OpBranch %12
+%12 = OpLabel
+OpBranch %9
+%11 = OpLabel
+OpReturn
+OpFunctionEnd
+%kill_ = OpFunction %void None %3
+%7 = OpLabel
+OpKill
+OpFunctionEnd
+)";
+  const std::string after =
+      R"(OpCapability Shader
+%1 = OpExtInstImport "GLSL.std.450"
+OpMemoryModel Logical GLSL450
+OpEntryPoint Fragment %main "main"
+OpExecutionMode %main OriginUpperLeft
+OpSource GLSL 330
+OpName %main "main"
+OpName %kill_ "kill("
+%void = OpTypeVoid
+%3 = OpTypeFunction %void
+%bool = OpTypeBool
+%true = OpConstantTrue %bool
+%main = OpFunction %void None %3
+%5 = OpLabel
+OpBranch %9
+%9 = OpLabel
+OpLoopMerge %11 %12 None
+OpBranch %13
+%13 = OpLabel
+OpBranchConditional %true %10 %11
+%10 = OpLabel
+OpKill
+%17 = OpLabel
+OpBranch %12
+%12 = OpLabel
+OpBranch %9
+%11 = OpLabel
+OpReturn
+OpFunctionEnd
+%kill_ = OpFunction %void None %3
+%7 = OpLabel
+OpKill
+OpFunctionEnd
+)";
+
+  SetAssembleOptions(SPV_TEXT_TO_BINARY_OPTION_PRESERVE_NUMERIC_IDS);
+  SinglePassRunAndCheck<InlineExhaustivePass>(before, after, false, true);
+}
+
 // TODO(greg-lunarg): Add tests to verify handling of these cases:
 //
 //    Empty modules