Generally speaking, upgrading Vitess is a safe and easy process because it is explicitly designed for it. This is because in YouTube we follow the practice of releasing new versions often (usually from the tip of the Git master branch).
Within the vtgate and vttablet components, we recommend to [canary](https://martinfowler.com/bliki/CanaryRelease.html) single instances, keyspaces and cells. Upgraded canary instances can "bake" for several hours or days to verify that the upgrade did not introduce a regression. Eventually, you can upgrade the remaining instances.
We recommend to automate the upgrade process with a configuration management software. It will reduce the possibility of human errors and simplify the process of managing all instances.
As of June 2016 we do not have templates for any major open-source configuration management software because our internal upgrade process is based on a proprietary software. Therefore, we invite open-source users to contribute such templates.
Any upgrade should be a rolling release i.e. usually one tablet at a time within a shard. This ensures that the remaining tablets continue serving live traffic and there is no interruption.