diff --git a/drivers/iommu/amd/iommu_v2.c b/drivers/iommu/amd/iommu_v2.c
index c259108ab6dd..0d175aed1d92 100644
--- a/drivers/iommu/amd/iommu_v2.c
+++ b/drivers/iommu/amd/iommu_v2.c
@@ -737,6 +737,13 @@ int amd_iommu_init_device(struct pci_dev *pdev, int pasids)
 
 	might_sleep();
 
+	/*
+	 * When memory encryption is active the device is likely not in a
+	 * direct-mapped domain. Forbid using IOMMUv2 functionality for now.
+	 */
+	if (mem_encrypt_active())
+		return -ENODEV;
+
 	if (!amd_iommu_v2_supported())
 		return -ENODEV;