diff --git a/browser/components/resistfingerprinting/test/browser/browser.toml b/browser/components/resistfingerprinting/test/browser/browser.toml
index 8b02e9aa091c..72503f90f353 100644
--- a/browser/components/resistfingerprinting/test/browser/browser.toml
+++ b/browser/components/resistfingerprinting/test/browser/browser.toml
@@ -88,10 +88,12 @@ https_first_disabled = true
 
 ["browser_dynamical_window_rounding.js"]
 https_first_disabled = true
-skip-if = [
-  "os == 'mac'", # Bug 1570812
-  "os == 'linux'", # Bug 1570812, Bug 1775698
-]
+skip-if = ["os == 'linux'"] # Bug 1570812, Bug 1775698
+
+["browser_exslt_time_precision.js"]
+
+["browser_exslt_timezone_load.js"]
+skip-if = ["os == 'win'"] # Bug 1918104
 
 ["browser_hwconcurrency_etp_iframes.js"]
 
@@ -152,11 +154,5 @@ https_first_disabled = true
 ["browser_roundedWindow_open_min_inner.js"]
 
 ["browser_spoofing_keyboard_event.js"]
-skip-if = ["(debug || asan) && os == 'linux' && bits == 64"] #Bug 1518179
 
 ["browser_timezone.js"]
-
-["browser_exslt_timezone_load.js"]
-skip-if = ["os == 'win'"] # Bug 1918104
-
-["browser_exslt_time_precision.js"]
diff --git a/browser/components/screenshots/tests/browser/browser.toml b/browser/components/screenshots/tests/browser/browser.toml
index 74ebb4e2d2bf..50715db7b476 100644
--- a/browser/components/screenshots/tests/browser/browser.toml
+++ b/browser/components/screenshots/tests/browser/browser.toml
@@ -43,9 +43,7 @@ skip-if = [
 ["browser_screenshots_face_focusable.js"]
 
 ["browser_screenshots_focus_test.js"]
-skip-if = [
-  "os == 'linux' && os_version == '18.04'", # Bug 1803618
-]
+skip-if = ["os == 'linux' && os_version == '18.04' && processor == 'x86_64' && debug && socketprocess_networking"] # Bug 1803618
 
 ["browser_screenshots_overlay_panel_sync.js"]
 
diff --git a/browser/components/sessionstore/test/browser.toml b/browser/components/sessionstore/test/browser.toml
index 2b665ef6857a..7d9320d037a1 100644
--- a/browser/components/sessionstore/test/browser.toml
+++ b/browser/components/sessionstore/test/browser.toml
@@ -58,7 +58,6 @@ run-if = ["crashreporter"]
 
 ["browser_async_window_flushing.js"]
 https_first_disabled = true
-skip-if = ["true"] # Bug 1775616
 
 ["browser_attributes.js"]
 
@@ -103,10 +102,7 @@ skip-if = ["os == 'linux' && os_version == '18.04' && processor == 'x86_64' && !
 ["browser_crashedTabs.js"]
 https_first_disabled = true
 run-if = ["crashreporter"]
-skip-if = [
-  "verify",
-  "os == 'mac'", # high frequency intermittent
-]
+skip-if = ["verify"]
 
 ["browser_docshell_uuid_consistency.js"]
 
@@ -115,7 +111,6 @@ skip-if = [
 ["browser_duplicate_tab_in_new_window.js"]
 
 ["browser_dying_cache.js"]
-skip-if = ["os == 'win'"] # bug 1331853
 
 ["browser_dynamic_frames.js"]
 
@@ -140,7 +135,6 @@ skip-if = ["asan"] # test runs too long
 ["browser_formdata_face.js"]
 
 ["browser_formdata_format.js"]
-skip-if = ["!debug && os == 'linux'"] # Bug 1535645
 
 ["browser_formdata_max_size.js"]
 
@@ -163,17 +157,15 @@ https_first_disabled = true
 run-if = ["crashreporter"]
 skip-if = [
   "asan",
-  "os == 'win' && fission && verify", # bug 1709907
-  "os == 'mac' && fission", # Bug 1711008; high frequency intermittent
+  "os == 'win' && verify", # bug 1709907
 ]
 
 ["browser_label_and_icon.js"]
 https_first_disabled = true
 skip-if = [
   "apple_silicon", # Disabled due to bleedover with other tests when run in regular suites; passes in "failures" jobs
-  "apple_catalina && !debug", # Bug 1638958
-  "os == 'linux' && !debug", # Bug 1638958
-  "win11_2009 && !debug", # Bug 1775605
+  "os == 'win' && os_version == '11.2009' && processor == 'x86_64' && opt && msix", # Bug 1775605
+  "os == 'mac' && os_version == '10.15' && processor == 'x86_64' && opt", # Bug 1638958
 ]
 
 ["browser_movePendingTabToNewWindow.js"]
@@ -181,7 +173,6 @@ https_first_disabled = true
 tags = "os_integration"
 
 ["browser_multiple_navigateAndRestore.js"]
-skip-if = ["os == 'linux' && debug"] #Bug 1570468
 
 ["browser_multiple_select_after_load.js"]
 
@@ -202,10 +193,7 @@ tags = "openUILinkIn"
 ["browser_pending_tabs.js"]
 
 ["browser_pinned_tabs.js"]
-skip-if = [
-  "debug",
-  "ccov", # Bug 1625525
-]
+skip-if = ["ccov"] # Bug 1625525
 
 ["browser_privatetabs.js"]
 
@@ -224,7 +212,7 @@ skip-if = ["true"] # Bug 1646894
 ["browser_restoreLastActionCorrectOrder.js"]
 
 ["browser_restoreLastClosedTabOrWindowOrSession.js"]
-skip-if = ["os == 'mac' && !debug"] # Bug 1838996
+skip-if = ["os == 'mac' && opt"] # Bug 1838996
 
 ["browser_restoreTabContainer.js"]
 
@@ -257,17 +245,12 @@ run-if = ["crashreporter"]
 ["browser_scrollPositions.js"]
 https_first_disabled = true
 run-if = ["fission"]
-skip-if = ["os == 'linux'"] # Bug 1716445
 
 ["browser_scrollPositionsReaderMode.js"]
 
 ["browser_sessionHistory.js"]
 https_first_disabled = true
 support-files = ["file_sessionHistory_hashchange.html"]
-skip-if = [
-  "os == 'linux'", # Bug 1775608
-  "os == 'mac' && os_version == '10.15' && debug", # Bug 1775608
-]
 
 ["browser_sessionStorage.js"]
 tags = "os_integration"
@@ -277,9 +260,6 @@ tags = "os_integration"
 ["browser_sessionStoreContainer.js"]
 
 ["browser_should_restore_tab.js"]
-skip-if = [
-  "os == 'linux' && os_version == '18.04' && debug", #Bug 1848488
-]
 
 ["browser_sizemodeBeforeMinimized.js"]
 
@@ -308,7 +288,6 @@ run-if = ["crashreporter"]
 
 ["browser_upgrade_backup.js"]
 skip-if = [
-  "debug",
   "asan",
   "tsan",
   "verify && debug && os == 'mac'", # Bug 1435394 disabled on Linux, OSX and Windows
diff --git a/browser/components/sessionstore/test/browser_oldformat.toml b/browser/components/sessionstore/test/browser_oldformat.toml
index e48d4b5beccc..147ab7be7514 100644
--- a/browser/components/sessionstore/test/browser_oldformat.toml
+++ b/browser/components/sessionstore/test/browser_oldformat.toml
@@ -165,24 +165,22 @@ skip-if = [
 skip-if = ["true"] # Bug 1380968
 
 ["browser_524745.js"]
-skip-if = [
-  "win10_2009 && !ccov", # Bug 1418627
-  "os == 'linux'", # Bug 1803187
-]
 
 ["browser_528776.js"]
 
 ["browser_579868.js"]
 
 ["browser_579879.js"]
-skip-if = ["os == 'linux' && (debug || asan)"] # Bug 1234404
 
 ["browser_581937.js"]
 
 ["browser_586068-apptabs.js"]
 
 ["browser_586068-apptabs_ondemand.js"]
-skip-if = ["verify && (os == 'mac' || os == 'win')"]
+skip-if = [
+  "verify && debug && os == 'win'",
+  "verify && debug && os == 'mac'",
+]
 
 ["browser_586068-browser_state_interrupted.js"]
 
@@ -210,7 +208,6 @@ https_first_disabled = true
 ["browser_595601-restore_hidden.js"]
 
 ["browser_597071.js"]
-skip-if = ["true"] # Needs to be rewritten as Marionette test, bug 995916
 
 ["browser_600545.js"]
 
@@ -231,10 +228,6 @@ https_first_disabled = true
 ["browser_615394-SSWindowState_events_undoCloseTab.js"]
 
 ["browser_615394-SSWindowState_events_undoCloseWindow.js"]
-skip-if = [
-  "os == 'win' && !debug", # Bug 1572554
-  "os == 'linux'",         # Bug 1572554
-]
 
 ["browser_618151.js"]
 
@@ -244,10 +237,6 @@ skip-if = [
 
 ["browser_625016.js"]
 run-if = ["os != 'mac'"] # not running on macOS where closing all windows doesn't quit the application
-skip-if = [
-  "os == 'linux'", # linux, Bug 1348583
-  "os == 'win' && debug", # Bug 1430977
-]
 
 ["browser_628270.js"]
 
@@ -296,6 +285,5 @@ skip-if = ["true"] # Bug 1284312, Bug 1341980, bug 1381451
 
 ["browser_906076_lazy_tabs.js"]
 https_first_disabled = true
-skip-if = ["os == 'linux' && os_version == '18.04'"] # bug 1446464
 
 ["browser_911547.js"]
diff --git a/browser/components/tabbrowser/test/browser/tabs/browser.toml b/browser/components/tabbrowser/test/browser/tabs/browser.toml
index fb2eb474179b..5734740ca176 100644
--- a/browser/components/tabbrowser/test/browser/tabs/browser.toml
+++ b/browser/components/tabbrowser/test/browser/tabs/browser.toml
@@ -23,9 +23,6 @@ prefs = [
 
 ["browser_audioTabIcon.js"]
 tags = "audiochannel"
-skip-if = [
-  "apple_silicon && !debug" # Bug 1862716
-]
 
 ["browser_bfcache_exemption_about_pages.js"]
 run-if = ["fission"]
@@ -215,7 +212,6 @@ support-files = ["file_observe_height_changes.html"]
 
 ["browser_new_tab_in_privilegedabout_process_pref.js"]
 https_first_disabled = true
-skip-if = ["os == 'linux' && debug"] # Bug 1581500.
 
 ["browser_new_tab_insert_position.js"]
 https_first_disabled = true
@@ -275,10 +271,6 @@ https_first_disabled = true
 ["browser_relatedTabs_reset.js"]
 
 ["browser_reload_deleted_file.js"]
-skip-if = [
-  "debug && os == 'mac'", #Bug 1421183, disabled on Linux/OSX for leaked windows
-  "debug && os == 'linux'", #Bug 1421183, disabled on Linux/OSX for leaked windows
-]
 
 ["browser_removeTabsToTheEnd.js"]
 
@@ -325,7 +317,6 @@ skip-if = ["true"] # Bug 1616418 Bug 1549985
 ["browser_tab_manager_drag.js"]
 
 ["browser_tab_manager_keyboard_access.js"]
-skip-if = ["true"] # Bug 1900477
 
 ["browser_tab_move_to_new_window_reload.js"]
 
diff --git a/browser/components/tests/browser/whats_new_page/browser.toml b/browser/components/tests/browser/whats_new_page/browser.toml
index 513aa6766355..f4660aea6e6e 100644
--- a/browser/components/tests/browser/whats_new_page/browser.toml
+++ b/browser/components/tests/browser/whats_new_page/browser.toml
@@ -20,4 +20,5 @@ prefs = [
 ["browser_whats_new_page.js"]
 
 ["include:./browser_whats_new_page_nimbus.toml"]
+
 ["include:./browser_whats_new_page_nimbus_disable.toml"]
diff --git a/browser/components/translations/tests/browser/browser.toml b/browser/components/translations/tests/browser/browser.toml
index 0cc8f3b730d3..f8e462f3529d 100644
--- a/browser/components/translations/tests/browser/browser.toml
+++ b/browser/components/translations/tests/browser/browser.toml
@@ -79,7 +79,6 @@ skip-if = ["true"]
 ["browser_translations_full_page_panel_never_translate_site_manual.js"]
 
 ["browser_translations_full_page_panel_retry.js"]
-skip-if = ["os == 'linux' && !debug"] # Bug 1863227
 
 ["browser_translations_full_page_panel_settings_unsupported_lang.js"]
 
diff --git a/browser/components/uitour/test/browser.toml b/browser/components/uitour/test/browser.toml
index 16b6f551573c..726cec4bedf5 100644
--- a/browser/components/uitour/test/browser.toml
+++ b/browser/components/uitour/test/browser.toml
@@ -55,16 +55,8 @@ skip-if = ["os == 'linux' && os_version == '18.04' && !debug && verify"]
 skip-if = ["os == 'linux' && os_version == '18.04' && !debug && verify"]
 
 ["browser_UITour_showProtectionReport.js"]
-skip-if = [
-  "os == 'linux' && os_version == '18.04' && asan", # Bug 1697217
-  "os == 'linux' && os_version == '18.04' && debug", # Bug 1697217
-  "os == 'linux' && os_version == '18.04' && tsan", # Bug 1697217
-]
 
 ["browser_UITour_sync.js"]
-skip-if = [
-  "os == 'linux' && os_version == '18.04'", # Bug 1678417
-]
 
 ["browser_UITour_toggleReaderMode.js"]
 skip-if = ["os == 'linux' && os_version == '18.04' && !debug && verify"]
diff --git a/browser/components/urlbar/tests/browser/browser.toml b/browser/components/urlbar/tests/browser/browser.toml
index 9d8a0f732665..bc19336e6a79 100644
--- a/browser/components/urlbar/tests/browser/browser.toml
+++ b/browser/components/urlbar/tests/browser/browser.toml
@@ -88,19 +88,14 @@ support-files = [
 ["browser_UrlbarInput_untrimOnUserInteraction.js"]
 
 ["browser_aboutHomeLoading.js"]
-skip-if = [
-  "tsan", # Intermittently times out, see 1622698 (frequent on TSan).
-  "os == 'linux' && bits == 64 && !debug", # Bug 1622698
-]
+skip-if = ["tsan"] # Intermittently times out, see 1622698 (frequent on TSan).
 
 ["browser_acknowledgeFeedbackAndDismissal.js"]
 
 ["browser_action_searchengine.js"]
 skip-if = [
   "os == 'linux' && asan",  # Bug 1834810
-  "os == 'linux' && debug", # Bug 1834810
   "os == 'win' && asan",  # Bug 1834810
-  "os == 'win' && debug", # Bug 1834810
 ]
 
 ["browser_action_searchengine_alias.js"]
@@ -339,9 +334,7 @@ support-files = [
 ]
 
 ["browser_oneOffs_heuristicRestyle.js"]
-skip-if = [
-  "os == 'linux' && bits == 64 && !debug", # Bug 1775811
-]
+skip-if = ["os == 'linux' && os_version == '18.04' && processor == 'x86_64' && opt && socketprocess_networking"] # Bug 1775811
 
 ["browser_oneOffs_keyModifiers.js"]
 support-files = [
@@ -486,11 +479,6 @@ https_first_disabled = true
 
 ["browser_searchMode_sessionStore.js"]
 https_first_disabled = true
-skip-if = [
-  "os == 'mac' && debug", # Bug 1671045, Bug 1849098
-  "os == 'linux' && (debug || tsan || asan)", # Bug 1849098
-  "os == 'win' && debug", # Bug 1849098
-]
 
 ["browser_searchMode_setURI.js"]
 https_first_disabled = true
@@ -508,7 +496,7 @@ support-files = [
 
 ["browser_searchSingleWordNotification.js"]
 https_first_disabled = true
-skip-if = ["os == 'linux' && bits == 64"] # Bug 1773830
+skip-if = ["os == 'linux' && os_version == '18.04' && processor == 'x86_64' && opt && a11y_checks && swgl"] # Bug 1773830
 
 ["browser_searchSuggestions.js"]
 support-files = [
@@ -723,9 +711,7 @@ support-files = [
 ]
 
 ["browser_view_selectionByMouse.js"]
-skip-if = [
-  "os == 'linux' && asan", # Bug 1789051
-]
+skip-if = ["os == 'linux' && asan"] # Bug 1789051
 
 ["browser_waitForLoadStartOrTimeout.js"]
 https_first_disabled = true
diff --git a/browser/components/urlbar/tests/quicksuggest/browser/browser.toml b/browser/components/urlbar/tests/quicksuggest/browser/browser.toml
index 723c92558c71..d9807ce00a8d 100644
--- a/browser/components/urlbar/tests/quicksuggest/browser/browser.toml
+++ b/browser/components/urlbar/tests/quicksuggest/browser/browser.toml
@@ -28,7 +28,7 @@ prefs = ["browser.bookmarks.testing.skipDefaultBookmarksImport=true"]
 ["browser_quicksuggest_merinoSessions.js"]
 
 ["browser_quicksuggest_onboardingDialog.js"]
-skip-if = ["os == 'linux' && bits == 64"] # Bug 1773830
+skip-if = ["os == 'linux' && os_version == '18.04' && processor == 'x86_64' && opt && a11y_checks && swgl"] # Bug 1773830
 
 ["browser_quicksuggest_pocket.js"]
 tags = "search-telemetry"