diff --git a/docshell/base/URIFixup.sys.mjs b/docshell/base/URIFixup.sys.mjs
index a0f31181feef..8009b7065d02 100644
--- a/docshell/base/URIFixup.sys.mjs
+++ b/docshell/base/URIFixup.sys.mjs
@@ -925,8 +925,8 @@ function fileURIFixup(uriString) {
       path = uriString.replace(/\//g, "\\");
     }
   } else {
-    // UNIX: Check if it starts with "/".
-    attemptFixup = uriString.startsWith("/");
+    // UNIX: Check if it starts with "/" or "~".
+    attemptFixup = /^[~/]/.test(uriString);
   }
   if (attemptFixup) {
     try {
diff --git a/docshell/test/unit/test_URIFixup_info.js b/docshell/test/unit/test_URIFixup_info.js
index 89514cb00c0b..66d5ff9c5b03 100644
--- a/docshell/test/unit/test_URIFixup_info.js
+++ b/docshell/test/unit/test_URIFixup_info.js
@@ -802,6 +802,18 @@ if (AppConstants.platform == "win") {
     affectedByDNSForSingleWordHosts: true,
   });
 } else {
+  const homeDir = Services.dirsvc.get("Home", Ci.nsIFile).path;
+
+  testcases.push({
+    input: "~",
+    fixedURI: `file://${homeDir}`,
+    protocolChange: true,
+  });
+  testcases.push({
+    input: "~/foo",
+    fixedURI: `file://${homeDir}/foo`,
+    protocolChange: true,
+  });
   testcases.push({
     input: "/some/file.txt",
     fixedURI: "file:///some/file.txt",