diff --git a/dom/webidl/Element.webidl b/dom/webidl/Element.webidl
index f4bf25bef9e8..8cc484419fd3 100644
--- a/dom/webidl/Element.webidl
+++ b/dom/webidl/Element.webidl
@@ -269,7 +269,7 @@ partial interface Element {
 
 // https://w3c.github.io/pointerlock/#extensions-to-the-element-interface
 partial interface Element {
-  [NeedsCallerType]
+  [NeedsCallerType, Pref="dom.pointer-lock.enabled"]
   void requestPointerLock();
 };
 
diff --git a/modules/libpref/init/all.js b/modules/libpref/init/all.js
index 7fc2a5ea9d59..363dd326c1cf 100644
--- a/modules/libpref/init/all.js
+++ b/modules/libpref/init/all.js
@@ -195,6 +195,12 @@ pref("dom.enable_performance_observer", true);
 // Enable requestIdleCallback API
 pref("dom.requestIdleCallback.enabled", true);
 
+// Enable Pointer Lock API
+// This is added for accessibility purpose. When user has no way to exit
+// pointer lock (e.g. no keyboard available), they can use this pref to
+// disable the Pointer Lock API altogether.
+pref("dom.pointer-lock.enabled", true);
+
 // Whether the Gamepad API is enabled
 pref("dom.gamepad.enabled", true);
 pref("dom.gamepad.test.enabled", false);