diff --git a/accessible/generic/Accessible.cpp b/accessible/generic/Accessible.cpp
index 583600e51234..4eeb391d5217 100644
--- a/accessible/generic/Accessible.cpp
+++ b/accessible/generic/Accessible.cpp
@@ -839,7 +839,7 @@ nsresult Accessible::HandleAccEvent(AccEvent* aEvent) {
     nsAutoCString strMarker;
     strMarker.AppendLiteral("A11y Event - ");
     strMarker.Append(strEventType);
-    profiler_add_marker(strMarker.get(), JS::ProfilingCategoryPair::OTHER);
+    PROFILER_ADD_MARKER(strMarker.get(), OTHER);
   }
 #endif
 
diff --git a/dom/base/TimeoutManager.cpp b/dom/base/TimeoutManager.cpp
index e44ddc0c57e1..387d24711e7d 100644
--- a/dom/base/TimeoutManager.cpp
+++ b/dom/base/TimeoutManager.cpp
@@ -155,11 +155,9 @@ void TimeoutManager::MoveIdleToActive() {
           int(elapsed.ToMilliseconds()), int(target.ToMilliseconds()),
           int(delta.ToMilliseconds()));
       // don't have end before start...
-      profiler_add_marker(
-          "setTimeout deferred release", JS::ProfilingCategoryPair::DOM,
-          MakeUnique<TextMarkerPayload>(
-              marker, delta.ToMilliseconds() >= 0 ? timeout->When() : now,
-              now));
+      PROFILER_ADD_MARKER_WITH_PAYLOAD(
+          "setTimeout deferred release", DOM, TextMarkerPayload,
+          (marker, delta.ToMilliseconds() >= 0 ? timeout->When() : now, now));
     }
 #endif
     num++;
@@ -906,11 +904,10 @@ void TimeoutManager::RunTimeout(const TimeStamp& aNow,
               int(elapsed.ToMilliseconds()), int(target.ToMilliseconds()),
               int(delta.ToMilliseconds()), int(runtime.ToMilliseconds()));
           // don't have end before start...
-          profiler_add_marker(
-              "setTimeout", JS::ProfilingCategoryPair::DOM,
-              MakeUnique<TextMarkerPayload>(
-                  marker, delta.ToMilliseconds() >= 0 ? timeout->When() : now,
-                  now));
+          PROFILER_ADD_MARKER_WITH_PAYLOAD(
+              "setTimeout", DOM, TextMarkerPayload,
+              (marker, delta.ToMilliseconds() >= 0 ? timeout->When() : now,
+               now));
         }
 #endif
 
diff --git a/dom/base/nsDOMNavigationTiming.cpp b/dom/base/nsDOMNavigationTiming.cpp
index f0e3b50a39cb..89d0b676bf18 100644
--- a/dom/base/nsDOMNavigationTiming.cpp
+++ b/dom/base/nsDOMNavigationTiming.cpp
@@ -165,9 +165,8 @@ void nsDOMNavigationTiming::NotifyLoadEventEnd() {
           int(elapsed.ToMilliseconds()), int(duration.ToMilliseconds()));
       DECLARE_DOCSHELL_AND_HISTORY_ID(mDocShell);
       PAGELOAD_LOG(("%s", marker.get()));
-      profiler_add_marker(
-          "DocumentLoad", JS::ProfilingCategoryPair::DOM,
-          MakeUnique<TextMarkerPayload>(marker, mNavigationStart, mLoadEventEnd,
+      PROFILER_ADD_MARKER_WITH_PAYLOAD("DocumentLoad", DOM, TextMarkerPayload,
+                                       (marker, mNavigationStart, mLoadEventEnd,
                                         docShellId, docShellHistoryId));
     }
 #endif
@@ -360,10 +359,9 @@ void nsDOMNavigationTiming::TTITimeout(nsITimer* aTimer) {
                            int(elapsedLongTask.ToMilliseconds()), spec.get());
 
     DECLARE_DOCSHELL_AND_HISTORY_ID(mDocShell);
-    profiler_add_marker(
-        "TTFI", JS::ProfilingCategoryPair::DOM,
-        MakeUnique<TextMarkerPayload>(marker, mNavigationStart, mTTFI,
-                                      docShellId, docShellHistoryId));
+    PROFILER_ADD_MARKER_WITH_PAYLOAD(
+        "TTFI", DOM, TextMarkerPayload,
+        (marker, mNavigationStart, mTTFI, docShellId, docShellHistoryId));
   }
 #endif
   return;
@@ -395,9 +393,9 @@ void nsDOMNavigationTiming::NotifyNonBlankPaintForRootContentDocument() {
               "and first non-blank paint");
     PAGELOAD_LOG(("%s", marker.get()));
     DECLARE_DOCSHELL_AND_HISTORY_ID(mDocShell);
-    profiler_add_marker(
-        "FirstNonBlankPaint", JS::ProfilingCategoryPair::DOM,
-        MakeUnique<TextMarkerPayload>(marker, mNavigationStart, mNonBlankPaint,
+    PROFILER_ADD_MARKER_WITH_PAYLOAD("FirstNonBlankPaint", DOM,
+                                     TextMarkerPayload,
+                                     (marker, mNavigationStart, mNonBlankPaint,
                                       docShellId, docShellHistoryId));
   }
 #endif
@@ -445,10 +443,10 @@ void nsDOMNavigationTiming::NotifyContentfulPaintForRootContentDocument(
               "and first non-blank paint");
     DECLARE_DOCSHELL_AND_HISTORY_ID(mDocShell);
     PAGELOAD_LOG(("%s", marker.get()));
-    profiler_add_marker("FirstContentfulPaint", JS::ProfilingCategoryPair::DOM,
-                        MakeUnique<TextMarkerPayload>(
-                            marker, mNavigationStart, mContentfulPaint,
-                            docShellId, docShellHistoryId));
+    PROFILER_ADD_MARKER_WITH_PAYLOAD(
+        "FirstContentfulPaint", DOM, TextMarkerPayload,
+        (marker, mNavigationStart, mContentfulPaint, docShellId,
+         docShellHistoryId));
   }
 #endif
 
@@ -495,10 +493,10 @@ void nsDOMNavigationTiming::NotifyDOMContentFlushedForRootContentDocument() {
               "and DOMContentFlushed");
     DECLARE_DOCSHELL_AND_HISTORY_ID(mDocShell);
     PAGELOAD_LOG(("%s", marker.get()));
-    profiler_add_marker("DOMContentFlushed", JS::ProfilingCategoryPair::DOM,
-                        MakeUnique<TextMarkerPayload>(
-                            marker, mNavigationStart, mDOMContentFlushed,
-                            docShellId, docShellHistoryId));
+    PROFILER_ADD_MARKER_WITH_PAYLOAD(
+        "DOMContentFlushed", DOM, TextMarkerPayload,
+        (marker, mNavigationStart, mDOMContentFlushed, docShellId,
+         docShellHistoryId));
   }
 #endif
 }
diff --git a/dom/events/EventDispatcher.cpp b/dom/events/EventDispatcher.cpp
index 6ff64ba483d3..c6aaee2bbd88 100644
--- a/dom/events/EventDispatcher.cpp
+++ b/dom/events/EventDispatcher.cpp
@@ -1027,20 +1027,18 @@ nsresult EventDispatcher::Dispatch(nsISupports* aTarget,
           nsCOMPtr<nsIDocShell> docShell;
           docShell = nsContentUtils::GetDocShellForEventTarget(aEvent->mTarget);
           DECLARE_DOCSHELL_AND_HISTORY_ID(docShell);
-          profiler_add_marker(
-              "DOMEvent", JS::ProfilingCategoryPair::DOM,
-              MakeUnique<DOMEventMarkerPayload>(
-                  typeStr, aEvent->mTimeStamp, "DOMEvent",
-                  TRACING_INTERVAL_START, docShellId, docShellHistoryId));
+          PROFILER_ADD_MARKER_WITH_PAYLOAD(
+              "DOMEvent", DOM, DOMEventMarkerPayload,
+              (typeStr, aEvent->mTimeStamp, "DOMEvent", TRACING_INTERVAL_START,
+               docShellId, docShellHistoryId));
 
           EventTargetChainItem::HandleEventTargetChain(chain, postVisitor,
                                                        aCallback, cd);
 
-          profiler_add_marker(
-              "DOMEvent", JS::ProfilingCategoryPair::DOM,
-              MakeUnique<DOMEventMarkerPayload>(
-                  typeStr, aEvent->mTimeStamp, "DOMEvent", TRACING_INTERVAL_END,
-                  docShellId, docShellHistoryId));
+          PROFILER_ADD_MARKER_WITH_PAYLOAD(
+              "DOMEvent", DOM, DOMEventMarkerPayload,
+              (typeStr, aEvent->mTimeStamp, "DOMEvent", TRACING_INTERVAL_END,
+               docShellId, docShellHistoryId));
         } else
 #endif
         {
diff --git a/dom/media/mediasink/VideoSink.cpp b/dom/media/mediasink/VideoSink.cpp
index 947d112bc0ec..6e889797ecc2 100644
--- a/dom/media/mediasink/VideoSink.cpp
+++ b/dom/media/mediasink/VideoSink.cpp
@@ -36,13 +36,13 @@ extern LazyLogModule gMediaDecoderLog;
   MOZ_LOG(gMediaDecoderLog, LogLevel::Verbose, (FMT(x, ##__VA_ARGS__)))
 
 #ifdef MOZ_GECKO_PROFILER
-#  define VSINK_ADD_PROFILER_MARKER(tag, markerTime, aTime, vTime)          \
-    do {                                                                    \
-      if (profiler_thread_is_being_profiled()) {                            \
-        profiler_add_marker(                                                \
-            tag, JS::ProfilingCategoryPair::GRAPHICS,                       \
-            MakeUnique<VideoFrameMarkerPayload>(markerTime, aTime, vTime)); \
-      }                                                                     \
+#  define VSINK_ADD_PROFILER_MARKER(tag, markerTime, aTime, vTime)    \
+    do {                                                              \
+      if (profiler_thread_is_being_profiled()) {                      \
+        PROFILER_ADD_MARKER_WITH_PAYLOAD(tag, GRAPHICS,               \
+                                         VideoFrameMarkerPayload,     \
+                                         (markerTime, aTime, vTime)); \
+      }                                                               \
     } while (0)
 
 class VideoFrameMarkerPayload : public ProfilerMarkerPayload {
diff --git a/dom/performance/Performance.cpp b/dom/performance/Performance.cpp
index 6e03e42ae9c1..e83d9c7168f8 100644
--- a/dom/performance/Performance.cpp
+++ b/dom/performance/Performance.cpp
@@ -226,10 +226,9 @@ void Performance::Mark(const nsAString& aName, ErrorResult& aRv) {
     nsCOMPtr<nsIDocShell> docShell =
         nsContentUtils::GetDocShellForEventTarget(et);
     DECLARE_DOCSHELL_AND_HISTORY_ID(docShell);
-    profiler_add_marker(
-        "UserTiming", JS::ProfilingCategoryPair::DOM,
-        MakeUnique<UserTimingMarkerPayload>(aName, TimeStamp::Now(), docShellId,
-                                            docShellHistoryId));
+    PROFILER_ADD_MARKER_WITH_PAYLOAD(
+        "UserTiming", DOM, UserTimingMarkerPayload,
+        (aName, TimeStamp::Now(), docShellId, docShellHistoryId));
   }
 #endif
 }
@@ -327,10 +326,10 @@ void Performance::Measure(const nsAString& aName,
     nsCOMPtr<nsIDocShell> docShell =
         nsContentUtils::GetDocShellForEventTarget(et);
     DECLARE_DOCSHELL_AND_HISTORY_ID(docShell);
-    profiler_add_marker("UserTiming", JS::ProfilingCategoryPair::DOM,
-                        MakeUnique<UserTimingMarkerPayload>(
-                            aName, startMark, endMark, startTimeStamp,
-                            endTimeStamp, docShellId, docShellHistoryId));
+    PROFILER_ADD_MARKER_WITH_PAYLOAD(
+        "UserTiming", DOM, UserTimingMarkerPayload,
+        (aName, startMark, endMark, startTimeStamp, endTimeStamp, docShellId,
+         docShellHistoryId));
   }
 #endif
 }
diff --git a/gfx/layers/Layers.cpp b/gfx/layers/Layers.cpp
index e362b24faaf9..e69975d3a658 100644
--- a/gfx/layers/Layers.cpp
+++ b/gfx/layers/Layers.cpp
@@ -2324,7 +2324,7 @@ void RecordCompositionPayloadsPresented(
             "Payload Presented, type: %d latency: %dms\n",
             int32_t(payload.mType),
             int32_t((presented - payload.mTimeStamp).ToMilliseconds()));
-        profiler_add_marker(marker.get(), JS::ProfilingCategoryPair::GRAPHICS);
+        PROFILER_ADD_MARKER(marker.get(), GRAPHICS);
       }
 #endif
 
diff --git a/gfx/layers/composite/CompositorScreenshotGrabber.cpp b/gfx/layers/composite/CompositorScreenshotGrabber.cpp
index dc3be46d733d..8b8798d28739 100644
--- a/gfx/layers/composite/CompositorScreenshotGrabber.cpp
+++ b/gfx/layers/composite/CompositorScreenshotGrabber.cpp
@@ -89,8 +89,8 @@ void CompositorScreenshotGrabber::MaybeProcessQueue() {
 
 void CompositorScreenshotGrabber::NotifyEmptyFrame() {
 #ifdef MOZ_GECKO_PROFILER
-  profiler_add_marker("NoCompositorScreenshot because nothing changed",
-                      JS::ProfilingCategoryPair::GRAPHICS);
+  PROFILER_ADD_MARKER("NoCompositorScreenshot because nothing changed",
+                      GRAPHICS);
 #endif
 }
 
diff --git a/gfx/layers/composite/ContainerLayerComposite.cpp b/gfx/layers/composite/ContainerLayerComposite.cpp
index b5e9eac7a8d8..c5725d9b29aa 100644
--- a/gfx/layers/composite/ContainerLayerComposite.cpp
+++ b/gfx/layers/composite/ContainerLayerComposite.cpp
@@ -102,9 +102,9 @@ static void PrintUniformityInfo(Layer* aLayer) {
   }
 
   Point translation = transform.As2D().GetTranslation();
-  profiler_add_marker("LayerTranslation", JS::ProfilingCategoryPair::GRAPHICS,
-                      MakeUnique<LayerTranslationMarkerPayload>(
-                          aLayer, translation, TimeStamp::Now()));
+  PROFILER_ADD_MARKER_WITH_PAYLOAD("LayerTranslation", GRAPHICS,
+                                   LayerTranslationMarkerPayload,
+                                   (aLayer, translation, TimeStamp::Now()));
 #endif
 }
 
diff --git a/gfx/layers/ipc/CompositorBridgeParent.cpp b/gfx/layers/ipc/CompositorBridgeParent.cpp
index bcd53db5d60c..598d362bf0a6 100644
--- a/gfx/layers/ipc/CompositorBridgeParent.cpp
+++ b/gfx/layers/ipc/CompositorBridgeParent.cpp
@@ -1976,8 +1976,8 @@ already_AddRefed<IAPZCTreeManager> CompositorBridgeParent::GetAPZCTreeManager(
 static void InsertVsyncProfilerMarker(TimeStamp aVsyncTimestamp) {
   MOZ_ASSERT(CompositorThreadHolder::IsInCompositorThread());
   if (profiler_thread_is_being_profiled()) {
-    profiler_add_marker("VsyncTimestamp", JS::ProfilingCategoryPair::GRAPHICS,
-                        MakeUnique<VsyncMarkerPayload>(aVsyncTimestamp));
+    PROFILER_ADD_MARKER_WITH_PAYLOAD("VsyncTimestamp", GRAPHICS,
+                                     VsyncMarkerPayload, (aVsyncTimestamp));
   }
 }
 #endif
diff --git a/gfx/layers/mlgpu/MLGPUScreenshotGrabber.cpp b/gfx/layers/mlgpu/MLGPUScreenshotGrabber.cpp
index dad635525d18..ab78a0493c8f 100644
--- a/gfx/layers/mlgpu/MLGPUScreenshotGrabber.cpp
+++ b/gfx/layers/mlgpu/MLGPUScreenshotGrabber.cpp
@@ -101,8 +101,8 @@ void MLGPUScreenshotGrabber::MaybeProcessQueue() {
 
 void MLGPUScreenshotGrabber::NotifyEmptyFrame() {
 #ifdef MOZ_GECKO_PROFILER
-  profiler_add_marker("NoCompositorScreenshot because nothing changed",
-                      JS::ProfilingCategoryPair::GRAPHICS);
+  PROFILER_ADD_MARKER("NoCompositorScreenshot because nothing changed",
+                      GRAPHICS);
 #endif
 }
 
diff --git a/layout/base/AutoProfilerStyleMarker.h b/layout/base/AutoProfilerStyleMarker.h
index 07d3229f10d0..fe18a8ab395f 100644
--- a/layout/base/AutoProfilerStyleMarker.h
+++ b/layout/base/AutoProfilerStyleMarker.h
@@ -39,11 +39,11 @@ class MOZ_RAII AutoProfilerStyleMarker {
       return;
     }
     ServoTraversalStatistics::sActive = false;
-    profiler_add_marker("Styles", JS::ProfilingCategoryPair::LAYOUT,
-                        MakeUnique<StyleMarkerPayload>(
-                            mStartTime, TimeStamp::Now(), std::move(mCause),
-                            ServoTraversalStatistics::sSingleton, mDocShellId,
-                            mDocShellHistoryId));
+    PROFILER_ADD_MARKER_WITH_PAYLOAD(
+        "Styles", LAYOUT, StyleMarkerPayload,
+        (mStartTime, TimeStamp::Now(), std::move(mCause),
+         ServoTraversalStatistics::sSingleton, mDocShellId,
+         mDocShellHistoryId));
   }
 
  private:
diff --git a/modules/libpref/Preferences.cpp b/modules/libpref/Preferences.cpp
index c84b7ede909a..346fccd49f07 100644
--- a/modules/libpref/Preferences.cpp
+++ b/modules/libpref/Preferences.cpp
@@ -4360,11 +4360,10 @@ struct Internals {
 
 #ifdef MOZ_GECKO_PROFILER
       if (profiler_feature_active(ProfilerFeature::PreferenceReads)) {
-        profiler_add_marker("PreferenceRead",
-                            JS::ProfilingCategoryPair::OTHER_PreferenceRead,
-                            MakeUnique<PrefMarkerPayload>(
-                                aPrefName, Some(aKind), Some(pref->Type()),
-                                PrefValueToString(aResult), TimeStamp::Now()));
+        PROFILER_ADD_MARKER_WITH_PAYLOAD(
+            "PreferenceRead", OTHER_PreferenceRead, PrefMarkerPayload,
+            (aPrefName, Some(aKind), Some(pref->Type()),
+             PrefValueToString(aResult), TimeStamp::Now()));
       }
 #endif
     }
@@ -4381,11 +4380,10 @@ struct Internals {
 
 #ifdef MOZ_GECKO_PROFILER
       if (profiler_feature_active(ProfilerFeature::PreferenceReads)) {
-        profiler_add_marker(
-            "PreferenceRead", JS::ProfilingCategoryPair::OTHER_PreferenceRead,
-            MakeUnique<PrefMarkerPayload>(
-                aName, Nothing() /* indicates Shared */, Some(pref->Type()),
-                PrefValueToString(aResult), TimeStamp::Now()));
+        PROFILER_ADD_MARKER_WITH_PAYLOAD(
+            "PreferenceRead", OTHER_PreferenceRead, PrefMarkerPayload,
+            (aName, Nothing() /* indicates Shared */, Some(pref->Type()),
+             PrefValueToString(aResult), TimeStamp::Now()));
       }
 #endif
     }
diff --git a/mozglue/baseprofiler/public/BaseProfiler.h b/mozglue/baseprofiler/public/BaseProfiler.h
index 5d5c0def4eb0..9a9b00425d50 100644
--- a/mozglue/baseprofiler/public/BaseProfiler.h
+++ b/mozglue/baseprofiler/public/BaseProfiler.h
@@ -65,6 +65,8 @@
                                                 categoryPair, ctx, flags)
 
 #  define BASE_PROFILER_ADD_MARKER(markerName, categoryPair)
+#  define BASE_PROFILER_ADD_MARKER_WITH_PAYLOAD( \
+      markerName, categoryPair, PayloadType, parenthesizedPayloadArgs)
 
 #  define MOZDECLARE_DOCSHELL_AND_HISTORY_ID(docShell)
 #  define BASE_PROFILER_TRACING(categoryString, markerName, categoryPair, kind)
@@ -695,6 +697,18 @@ class MOZ_RAII AutoProfilerStats {
 
 MFBT_API void profiler_add_marker(const char* aMarkerName,
                                   ProfilingCategoryPair aCategoryPair);
+
+// `PayloadType` is a sub-class of BaseMarkerPayload, `parenthesizedPayloadArgs`
+// is the argument list used to construct that `PayloadType`. E.g.:
+// `BASE_PROFILER_ADD_MARKER_WITH_PAYLOAD("Load", DOM, TextMarkerPayload,
+//                                        ("text", start, end, ds, dsh))`
+#  define BASE_PROFILER_ADD_MARKER_WITH_PAYLOAD(                       \
+      markerName, categoryPair, PayloadType, parenthesizedPayloadArgs) \
+    ::mozilla::baseprofiler::profiler_add_marker(                      \
+        markerName,                                                    \
+        ::mozilla::baseprofiler::ProfilingCategoryPair::categoryPair,  \
+        ::mozilla::MakeUnique<PayloadType> parenthesizedPayloadArgs)
+
 MFBT_API void profiler_add_marker(const char* aMarkerName,
                                   ProfilingCategoryPair aCategoryPair,
                                   UniquePtr<ProfilerMarkerPayload> aPayload);
diff --git a/tools/profiler/gecko/ProfilerIOInterposeObserver.cpp b/tools/profiler/gecko/ProfilerIOInterposeObserver.cpp
index f338c4d73bfe..5138d343a81e 100644
--- a/tools/profiler/gecko/ProfilerIOInterposeObserver.cpp
+++ b/tools/profiler/gecko/ProfilerIOInterposeObserver.cpp
@@ -18,10 +18,9 @@ void ProfilerIOInterposeObserver::Observe(Observation& aObservation) {
 
   nsString filename;
   aObservation.Filename(filename);
-  profiler_add_marker(
-      "FileIO", JS::ProfilingCategoryPair::OTHER,
-      MakeUnique<FileIOMarkerPayload>(
-          aObservation.ObservedOperationString(), aObservation.Reference(),
-          NS_ConvertUTF16toUTF8(filename).get(), aObservation.Start(),
-          aObservation.End(), std::move(stack)));
+  PROFILER_ADD_MARKER_WITH_PAYLOAD(
+      "FileIO", OTHER, FileIOMarkerPayload,
+      (aObservation.ObservedOperationString(), aObservation.Reference(),
+       NS_ConvertUTF16toUTF8(filename).get(), aObservation.Start(),
+       aObservation.End(), std::move(stack)));
 }
diff --git a/tools/profiler/gecko/nsProfiler.cpp b/tools/profiler/gecko/nsProfiler.cpp
index 6fb583888e4f..4a3a18b26386 100644
--- a/tools/profiler/gecko/nsProfiler.cpp
+++ b/tools/profiler/gecko/nsProfiler.cpp
@@ -173,7 +173,7 @@ nsProfiler::ResumeSampling() {
 
 NS_IMETHODIMP
 nsProfiler::AddMarker(const char* aMarker) {
-  profiler_add_marker(aMarker, JS::ProfilingCategoryPair::OTHER);
+  PROFILER_ADD_MARKER(aMarker, OTHER);
   return NS_OK;
 }
 
diff --git a/tools/profiler/public/GeckoProfiler.h b/tools/profiler/public/GeckoProfiler.h
index 458612d3deb5..d4eded0fbbc2 100644
--- a/tools/profiler/public/GeckoProfiler.h
+++ b/tools/profiler/public/GeckoProfiler.h
@@ -51,6 +51,8 @@
                                            ctx, flags)
 
 #  define PROFILER_ADD_MARKER(markerName, categoryPair)
+#  define PROFILER_ADD_MARKER_WITH_PAYLOAD(markerName, categoryPair, \
+                                           PayloadType, payloadArgs)
 #  define PROFILER_ADD_NETWORK_MARKER(uri, pri, channel, type, start, end, \
                                       count, cache, timings, redirect)
 
@@ -675,10 +677,21 @@ mozilla::Maybe<ProfilerBufferInfo> profiler_get_buffer_info();
 // mode.
 
 #  define PROFILER_ADD_MARKER(markerName, categoryPair) \
-    profiler_add_marker(markerName, JS::ProfilingCategoryPair::categoryPair)
+    ::profiler_add_marker(markerName, ::JS::ProfilingCategoryPair::categoryPair)
 
 void profiler_add_marker(const char* aMarkerName,
                          JS::ProfilingCategoryPair aCategoryPair);
+
+// `PayloadType` is a sub-class of MarkerPayload, `parenthesizedPayloadArgs` is
+// the argument list used to construct that `PayloadType`. E.g.:
+// `PROFILER_ADD_MARKER_WITH_PAYLOAD("Load", DOM, TextMarkerPayload,
+//                                   ("text", start, end, ds, dsh))`
+#  define PROFILER_ADD_MARKER_WITH_PAYLOAD(                            \
+      markerName, categoryPair, PayloadType, parenthesizedPayloadArgs) \
+    ::profiler_add_marker(                                             \
+        markerName, ::JS::ProfilingCategoryPair::categoryPair,         \
+        ::mozilla::MakeUnique<PayloadType> parenthesizedPayloadArgs)
+
 void profiler_add_marker(const char* aMarkerName,
                          JS::ProfilingCategoryPair aCategoryPair,
                          mozilla::UniquePtr<ProfilerMarkerPayload> aPayload);
diff --git a/tools/profiler/tests/gtest/GeckoProfiler.cpp b/tools/profiler/tests/gtest/GeckoProfiler.cpp
index 31c0bc448dd5..7689a491bc6f 100644
--- a/tools/profiler/tests/gtest/GeckoProfiler.cpp
+++ b/tools/profiler/tests/gtest/GeckoProfiler.cpp
@@ -530,18 +530,17 @@ TEST(GeckoProfiler, Markers)
 
   { AUTO_PROFILER_TRACING("C", "A", OTHER); }
 
-  profiler_add_marker("M1", JS::ProfilingCategoryPair::OTHER);
-  profiler_add_marker("M2", JS::ProfilingCategoryPair::OTHER,
-                      MakeUnique<TracingMarkerPayload>("C", TRACING_EVENT));
+  PROFILER_ADD_MARKER("M1", OTHER);
+  PROFILER_ADD_MARKER_WITH_PAYLOAD("M2", OTHER, TracingMarkerPayload,
+                                   ("C", TRACING_EVENT));
   PROFILER_ADD_MARKER("M3", OTHER);
-  profiler_add_marker("M4", JS::ProfilingCategoryPair::OTHER,
-                      MakeUnique<TracingMarkerPayload>(
-                          "C", TRACING_EVENT, mozilla::Nothing(),
-                          mozilla::Nothing(), profiler_get_backtrace()));
+  PROFILER_ADD_MARKER_WITH_PAYLOAD(
+      "M4", OTHER, TracingMarkerPayload,
+      ("C", TRACING_EVENT, mozilla::Nothing(), mozilla::Nothing(),
+       profiler_get_backtrace()));
 
   for (int i = 0; i < 10; i++) {
-    profiler_add_marker("M5", JS::ProfilingCategoryPair::OTHER,
-                        MakeUnique<GTestMarkerPayload>(i));
+    PROFILER_ADD_MARKER_WITH_PAYLOAD("M5", OTHER, GTestMarkerPayload, (i));
   }
 
   // Create two strings: one that is the maximum allowed length, and one that
@@ -628,8 +627,7 @@ TEST(GeckoProfiler, Markers)
   ASSERT_TRUE(GTestMarkerPayload::sNumDestroyed == 10);
 
   for (int i = 0; i < 10; i++) {
-    profiler_add_marker("M5", JS::ProfilingCategoryPair::OTHER,
-                        MakeUnique<GTestMarkerPayload>(i));
+    PROFILER_ADD_MARKER_WITH_PAYLOAD("M5", OTHER, GTestMarkerPayload, (i));
   }
 
   // Warning: this could be racy
@@ -659,11 +657,9 @@ TEST(GeckoProfiler, DurationLimit)
   GTestMarkerPayload::sNumStreamed = 0;
   GTestMarkerPayload::sNumDestroyed = 0;
 
-  profiler_add_marker("M1", JS::ProfilingCategoryPair::OTHER,
-                      MakeUnique<GTestMarkerPayload>(1));
+  PROFILER_ADD_MARKER_WITH_PAYLOAD("M1", OTHER, GTestMarkerPayload, (1));
   PR_Sleep(PR_MillisecondsToInterval(1100));
-  profiler_add_marker("M2", JS::ProfilingCategoryPair::OTHER,
-                      MakeUnique<GTestMarkerPayload>(2));
+  PROFILER_ADD_MARKER_WITH_PAYLOAD("M2", OTHER, GTestMarkerPayload, (2));
   PR_Sleep(PR_MillisecondsToInterval(500));
 
   SpliceableChunkedJSONWriter w;
diff --git a/xpcom/base/CycleCollectedJSRuntime.cpp b/xpcom/base/CycleCollectedJSRuntime.cpp
index d850836d0851..fd0d7749fe4f 100644
--- a/xpcom/base/CycleCollectedJSRuntime.cpp
+++ b/xpcom/base/CycleCollectedJSRuntime.cpp
@@ -841,17 +841,15 @@ void CycleCollectedJSRuntime::GCSliceCallback(JSContext* aContext,
 #ifdef MOZ_GECKO_PROFILER
   if (profiler_thread_is_being_profiled()) {
     if (aProgress == JS::GC_CYCLE_END) {
-      profiler_add_marker(
-          "GCMajor", JS::ProfilingCategoryPair::GCCC,
-          MakeUnique<GCMajorMarkerPayload>(aDesc.startTime(aContext),
-                                           aDesc.endTime(aContext),
-                                           aDesc.formatJSONProfiler(aContext)));
+      PROFILER_ADD_MARKER_WITH_PAYLOAD(
+          "GCMajor", GCCC, GCMajorMarkerPayload,
+          (aDesc.startTime(aContext), aDesc.endTime(aContext),
+           aDesc.formatJSONProfiler(aContext)));
     } else if (aProgress == JS::GC_SLICE_END) {
-      profiler_add_marker(
-          "GCSlice", JS::ProfilingCategoryPair::GCCC,
-          MakeUnique<GCSliceMarkerPayload>(
-              aDesc.lastSliceStart(aContext), aDesc.lastSliceEnd(aContext),
-              aDesc.sliceToJSONProfiler(aContext)));
+      PROFILER_ADD_MARKER_WITH_PAYLOAD(
+          "GCSlice", GCCC, GCSliceMarkerPayload,
+          (aDesc.lastSliceStart(aContext), aDesc.lastSliceEnd(aContext),
+           aDesc.sliceToJSONProfiler(aContext)));
     }
   }
 #endif
@@ -930,10 +928,10 @@ void CycleCollectedJSRuntime::GCNurseryCollectionCallback(
 #ifdef MOZ_GECKO_PROFILER
   else if (aProgress == JS::GCNurseryProgress::GC_NURSERY_COLLECTION_END &&
            profiler_thread_is_being_profiled()) {
-    profiler_add_marker("GCMinor", JS::ProfilingCategoryPair::GCCC,
-                        MakeUnique<GCMinorMarkerPayload>(
-                            self->mLatestNurseryCollectionStart,
-                            TimeStamp::Now(), JS::MinorGcToJSON(aContext)));
+    PROFILER_ADD_MARKER_WITH_PAYLOAD(
+        "GCMinor", GCCC, GCMinorMarkerPayload,
+        (self->mLatestNurseryCollectionStart, TimeStamp::Now(),
+         JS::MinorGcToJSON(aContext)));
   }
 #endif
 
diff --git a/xpcom/base/Logging.cpp b/xpcom/base/Logging.cpp
index aa6ce93168c0..ab6ff1c86b61 100644
--- a/xpcom/base/Logging.cpp
+++ b/xpcom/base/Logging.cpp
@@ -407,9 +407,8 @@ class LogModuleManager {
 
 #ifdef MOZ_GECKO_PROFILER
     if (mAddProfilerMarker && profiler_is_active()) {
-      profiler_add_marker(
-          "LogMessages", JS::ProfilingCategoryPair::OTHER,
-          MakeUnique<LogMarkerPayload>(aName, buffToWrite, TimeStamp::Now()));
+      PROFILER_ADD_MARKER_WITH_PAYLOAD("LogMessages", OTHER, LogMarkerPayload,
+                                       (aName, buffToWrite, TimeStamp::Now()));
     }
 #endif
 
diff --git a/xpcom/threads/nsThread.cpp b/xpcom/threads/nsThread.cpp
index 23fdd2bbb474..b8678bae0dfd 100644
--- a/xpcom/threads/nsThread.cpp
+++ b/xpcom/threads/nsThread.cpp
@@ -1237,11 +1237,10 @@ nsThread::ProcessNextEvent(bool aMayWait, bool* aResult) {
           mLastLongTaskEnd = now;
 #ifdef MOZ_GECKO_PROFILER
           if (profiler_thread_is_being_profiled()) {
-            profiler_add_marker(
+            PROFILER_ADD_MARKER_WITH_PAYLOAD(
                 (priority != EventQueuePriority::Idle) ? "LongTask"
                                                        : "LongIdleTask",
-                JS::ProfilingCategoryPair::OTHER,
-                MakeUnique<LongTaskMarkerPayload>(mCurrentEventStart, now));
+                OTHER, LongTaskMarkerPayload, (mCurrentEventStart, now));
           }
 #endif
         }