diff --git a/browser/base/content/test/tabs/browser.ini b/browser/base/content/test/tabs/browser.ini
index f8d5b51d9bb1..4b6641084eb9 100644
--- a/browser/base/content/test/tabs/browser.ini
+++ b/browser/base/content/test/tabs/browser.ini
@@ -13,6 +13,8 @@ skip-if = !e10s # Tab spinner is e10s only.
 [browser_tabSwitchPrintPreview.js]
 skip-if = os == 'mac'
 [browser_navigatePinnedTab.js]
+[browser_new_file_whitelisted_http_tab.js]
+skip-if = !e10s # Test only relevant for e10s.
 [browser_new_web_tab_in_file_process_pref.js]
 skip-if = !e10s # Pref and test only relevant for e10s.
 [browser_opened_file_tab_navigated_to_web.js]
diff --git a/browser/base/content/test/tabs/browser_new_file_whitelisted_http_tab.js b/browser/base/content/test/tabs/browser_new_file_whitelisted_http_tab.js
new file mode 100644
index 000000000000..8e0d99458de6
--- /dev/null
+++ b/browser/base/content/test/tabs/browser_new_file_whitelisted_http_tab.js
@@ -0,0 +1,27 @@
+/* -*- indent-tabs-mode: nil; js-indent-level: 2 -*- */
+/* vim: set ft=javascript ts=2 et sw=2 tw=80: */
+
+const TEST_HTTP = "http://example.org/";
+
+// Test for bug 1378377.
+add_task(async function() {
+  // Set prefs to ensure file content process.
+  await SpecialPowers.pushPrefEnv(
+    {set: [["browser.tabs.remote.separateFileUriProcess", true]]});
+
+  await BrowserTestUtils.withNewTab(TEST_HTTP, async function(fileBrowser) {
+    is(fileBrowser.remoteType, E10SUtils.WEB_REMOTE_TYPE,
+      "Check that tab normally has web remote type.");
+  });
+
+  // Set prefs to whitelist TEST_HTTP for file:// URI use.
+  await SpecialPowers.pushPrefEnv(
+    {set: [["capability.policy.policynames", "allowFileURI"],
+           ["capability.policy.allowFileURI.sites", TEST_HTTP],
+           ["capability.policy.allowFileURI.checkloaduri.enabled", "allAccess"]]});
+
+  await BrowserTestUtils.withNewTab(TEST_HTTP, async function(fileBrowser) {
+    is(fileBrowser.remoteType, E10SUtils.FILE_REMOTE_TYPE,
+      "Check that tab now has file remote type.");
+  });
+});