diff --git a/dom/base/nsGlobalWindow.cpp b/dom/base/nsGlobalWindow.cpp
index b1b56df35b2b..506d975c6e83 100644
--- a/dom/base/nsGlobalWindow.cpp
+++ b/dom/base/nsGlobalWindow.cpp
@@ -11152,15 +11152,14 @@ nsGlobalWindow::ShowSlowScriptDialog()
     buttonFlags += nsIPrompt::BUTTON_TITLE_IS_STRING * nsIPrompt::BUTTON_POS_2;
 
   // Null out the operation callback while we're re-entering JS here.
-  JSRuntime* rt = JS_GetRuntime(cx);
-  JSInterruptCallback old = JS_SetInterruptCallback(rt, nullptr);
+  JSInterruptCallback old = JS_SetInterruptCallback(cx, nullptr);
 
   // Open the dialog.
   rv = prompt->ConfirmEx(title, msg, buttonFlags, waitButton, stopButton,
                          debugButton, neverShowDlg, &neverShowDlgChk,
                          &buttonPressed);
 
-  JS_SetInterruptCallback(rt, old);
+  JS_SetInterruptCallback(cx, old);
 
   if (NS_SUCCEEDED(rv) && (buttonPressed == 0)) {
     return neverShowDlgChk ? AlwaysContinueSlowScript : ContinueSlowScript;
diff --git a/dom/workers/RuntimeService.cpp b/dom/workers/RuntimeService.cpp
index 886ea41b1b77..91be4def722b 100644
--- a/dom/workers/RuntimeService.cpp
+++ b/dom/workers/RuntimeService.cpp
@@ -793,7 +793,7 @@ InitJSContextForWorker(WorkerPrivate* aWorkerPrivate, JSRuntime* aRuntime)
     return nullptr;
   }
 
-  JS_SetInterruptCallback(aRuntime, InterruptCallback);
+  JS_SetInterruptCallback(workerCx, InterruptCallback);
 
   js::SetCTypesActivityCallback(aRuntime, CTypesActivityCallback);
 
diff --git a/js/src/jsapi.cpp b/js/src/jsapi.cpp
index 8f6967e453e8..2ff85e809504 100644
--- a/js/src/jsapi.cpp
+++ b/js/src/jsapi.cpp
@@ -4625,17 +4625,17 @@ JS_CheckForInterrupt(JSContext* cx)
 }
 
 JS_PUBLIC_API(JSInterruptCallback)
-JS_SetInterruptCallback(JSRuntime* rt, JSInterruptCallback callback)
+JS_SetInterruptCallback(JSContext* cx, JSInterruptCallback callback)
 {
-    JSInterruptCallback old = rt->interruptCallback;
-    rt->interruptCallback = callback;
+    JSInterruptCallback old = cx->interruptCallback;
+    cx->interruptCallback = callback;
     return old;
 }
 
 JS_PUBLIC_API(JSInterruptCallback)
-JS_GetInterruptCallback(JSRuntime* rt)
+JS_GetInterruptCallback(JSContext* cx)
 {
-    return rt->interruptCallback;
+    return cx->interruptCallback;
 }
 
 /************************************************************************/
@@ -4644,25 +4644,25 @@ JS_GetInterruptCallback(JSRuntime* rt)
  * Promises.
  */
 JS_PUBLIC_API(void)
-JS::SetGetIncumbentGlobalCallback(JSRuntime* rt, JSGetIncumbentGlobalCallback callback)
+JS::SetGetIncumbentGlobalCallback(JSContext* cx, JSGetIncumbentGlobalCallback callback)
 {
-    rt->getIncumbentGlobalCallback = callback;
+    cx->getIncumbentGlobalCallback = callback;
 }
 
 JS_PUBLIC_API(void)
-JS::SetEnqueuePromiseJobCallback(JSRuntime* rt, JSEnqueuePromiseJobCallback callback,
+JS::SetEnqueuePromiseJobCallback(JSContext* cx, JSEnqueuePromiseJobCallback callback,
                                  void* data /* = nullptr */)
 {
-    rt->enqueuePromiseJobCallback = callback;
-    rt->enqueuePromiseJobCallbackData = data;
+    cx->enqueuePromiseJobCallback = callback;
+    cx->enqueuePromiseJobCallbackData = data;
 }
 
 extern JS_PUBLIC_API(void)
-JS::SetPromiseRejectionTrackerCallback(JSRuntime* rt, JSPromiseRejectionTrackerCallback callback,
+JS::SetPromiseRejectionTrackerCallback(JSContext* cx, JSPromiseRejectionTrackerCallback callback,
                                        void* data /* = nullptr */)
 {
-    rt->promiseRejectionTrackerCallback = callback;
-    rt->promiseRejectionTrackerCallbackData = data;
+    cx->promiseRejectionTrackerCallback = callback;
+    cx->promiseRejectionTrackerCallbackData = data;
 }
 
 JS_PUBLIC_API(JSObject*)
diff --git a/js/src/jsapi.h b/js/src/jsapi.h
index 546759e66fc2..43ba7697cb5d 100644
--- a/js/src/jsapi.h
+++ b/js/src/jsapi.h
@@ -4308,10 +4308,10 @@ JS_CheckForInterrupt(JSContext* cx);
  * is disconnected before attempting such re-entry.
  */
 extern JS_PUBLIC_API(JSInterruptCallback)
-JS_SetInterruptCallback(JSRuntime* rt, JSInterruptCallback callback);
+JS_SetInterruptCallback(JSContext* cx, JSInterruptCallback callback);
 
 extern JS_PUBLIC_API(JSInterruptCallback)
-JS_GetInterruptCallback(JSRuntime* rt);
+JS_GetInterruptCallback(JSContext* cx);
 
 extern JS_PUBLIC_API(void)
 JS_RequestInterruptCallback(JSRuntime* rt);
@@ -4326,7 +4326,7 @@ namespace JS {
  * See dom/base/ScriptSettings.h for details.
  */
 extern JS_PUBLIC_API(void)
-SetGetIncumbentGlobalCallback(JSRuntime* rt, JSGetIncumbentGlobalCallback callback);
+SetGetIncumbentGlobalCallback(JSContext* cx, JSGetIncumbentGlobalCallback callback);
 
 /**
  * Sets the callback that's invoked whenever a Promise job should be enqeued.
@@ -4338,7 +4338,7 @@ SetGetIncumbentGlobalCallback(JSRuntime* rt, JSGetIncumbentGlobalCallback callba
  * passed here as arguments.
  */
 extern JS_PUBLIC_API(void)
-SetEnqueuePromiseJobCallback(JSRuntime* rt, JSEnqueuePromiseJobCallback callback,
+SetEnqueuePromiseJobCallback(JSContext* cx, JSEnqueuePromiseJobCallback callback,
                              void* data = nullptr);
 
 /**
@@ -4347,7 +4347,7 @@ SetEnqueuePromiseJobCallback(JSRuntime* rt, JSEnqueuePromiseJobCallback callback
  * without a handler gets a handler attached.
  */
 extern JS_PUBLIC_API(void)
-SetPromiseRejectionTrackerCallback(JSRuntime* rt, JSPromiseRejectionTrackerCallback callback,
+SetPromiseRejectionTrackerCallback(JSContext* cx, JSPromiseRejectionTrackerCallback callback,
                                    void* data = nullptr);
 
 /**
diff --git a/js/src/shell/js.cpp b/js/src/shell/js.cpp
index 735b672de90a..941e1ff5aa97 100644
--- a/js/src/shell/js.cpp
+++ b/js/src/shell/js.cpp
@@ -711,8 +711,7 @@ SetPromiseRejectionTrackerCallback(JSContext* cx, unsigned argc, Value* vp)
     }
 
     GetShellRuntime(cx)->promiseRejectionTrackerCallback = args[0];
-    JS::SetPromiseRejectionTrackerCallback(cx->runtime(),
-                                           ForwardingPromiseRejectionTrackerCallback);
+    JS::SetPromiseRejectionTrackerCallback(cx, ForwardingPromiseRejectionTrackerCallback);
 
 #endif // SPIDERMONKEY_PROMISE
     args.rval().setUndefined();
@@ -2960,8 +2959,8 @@ WorkerMain(void* arg)
 
 #ifdef SPIDERMONKEY_PROMISE
     sr->jobQueue.init(cx, JobQueue(SystemAllocPolicy()));
-    JS::SetEnqueuePromiseJobCallback(rt, ShellEnqueuePromiseJobCallback);
-    JS::SetGetIncumbentGlobalCallback(rt, ShellGetIncumbentGlobalCallback);
+    JS::SetEnqueuePromiseJobCallback(cx, ShellEnqueuePromiseJobCallback);
+    JS::SetGetIncumbentGlobalCallback(cx, ShellGetIncumbentGlobalCallback);
 #endif // SPIDERMONKEY_PROMISE
 
     EnvironmentPreparer environmentPreparer(cx);
@@ -2994,8 +2993,8 @@ WorkerMain(void* arg)
     JS::SetLargeAllocationFailureCallback(cx, nullptr, nullptr);
 
 #ifdef SPIDERMONKEY_PROMISE
-    JS::SetGetIncumbentGlobalCallback(rt, nullptr);
-    JS::SetEnqueuePromiseJobCallback(rt, nullptr);
+    JS::SetGetIncumbentGlobalCallback(cx, nullptr);
+    JS::SetEnqueuePromiseJobCallback(cx, nullptr);
     sr->jobQueue.reset();
 #endif // SPIDERMONKEY_PROMISE
 
@@ -7400,7 +7399,7 @@ main(int argc, char** argv, char** envp)
     JS_SetSecurityCallbacks(cx, &ShellPrincipals::securityCallbacks);
     JS_InitDestroyPrincipalsCallback(cx, ShellPrincipals::destroy);
 
-    JS_SetInterruptCallback(rt, ShellInterruptCallback);
+    JS_SetInterruptCallback(cx, ShellInterruptCallback);
     JS::SetBuildIdOp(cx, ShellBuildId);
     JS::SetAsmJSCacheOps(cx, &asmJSCacheOps);
 
@@ -7413,8 +7412,8 @@ main(int argc, char** argv, char** envp)
 
 #ifdef SPIDERMONKEY_PROMISE
     sr->jobQueue.init(cx, JobQueue(SystemAllocPolicy()));
-    JS::SetEnqueuePromiseJobCallback(rt, ShellEnqueuePromiseJobCallback);
-    JS::SetGetIncumbentGlobalCallback(rt, ShellGetIncumbentGlobalCallback);
+    JS::SetEnqueuePromiseJobCallback(cx, ShellEnqueuePromiseJobCallback);
+    JS::SetGetIncumbentGlobalCallback(cx, ShellGetIncumbentGlobalCallback);
 #endif // SPIDERMONKEY_PROMISE
 
     EnvironmentPreparer environmentPreparer(cx);
@@ -7446,8 +7445,8 @@ main(int argc, char** argv, char** envp)
     JS::SetLargeAllocationFailureCallback(cx, nullptr, nullptr);
 
 #ifdef SPIDERMONKEY_PROMISE
-    JS::SetGetIncumbentGlobalCallback(rt, nullptr);
-    JS::SetEnqueuePromiseJobCallback(rt, nullptr);
+    JS::SetGetIncumbentGlobalCallback(cx, nullptr);
+    JS::SetEnqueuePromiseJobCallback(cx, nullptr);
     sr->jobQueue.reset();
 #endif // SPIDERMONKEY_PROMISE
 
diff --git a/js/xpconnect/src/XPCJSRuntime.cpp b/js/xpconnect/src/XPCJSRuntime.cpp
index 9ae771f4a1b6..fc43b329f439 100644
--- a/js/xpconnect/src/XPCJSRuntime.cpp
+++ b/js/xpconnect/src/XPCJSRuntime.cpp
@@ -3568,7 +3568,7 @@ XPCJSRuntime::Initialize()
 #endif
     JS_SetAccumulateTelemetryCallback(cx, AccumulateTelemetryCallback);
     js::SetActivityCallback(cx, ActivityCallback, this);
-    JS_SetInterruptCallback(runtime, InterruptCallback);
+    JS_SetInterruptCallback(cx, InterruptCallback);
     js::SetWindowProxyClass(cx, &OuterWindowProxyClass);
 #ifdef MOZ_CRASHREPORTER
     js::AutoEnterOOMUnsafeRegion::setAnnotateOOMAllocationSizeCallback(
diff --git a/js/xpconnect/src/XPCShellImpl.cpp b/js/xpconnect/src/XPCShellImpl.cpp
index 247240daab2a..5502565053f8 100644
--- a/js/xpconnect/src/XPCShellImpl.cpp
+++ b/js/xpconnect/src/XPCShellImpl.cpp
@@ -1425,12 +1425,13 @@ XRE_XPCShellMain(int argc, char** argv, char** envp,
         // reason to bother.
         sScriptedInterruptCallback = new PersistentRootedValue;
         sScriptedInterruptCallback->init(rt, UndefinedValue());
-        JS_SetInterruptCallback(rt, XPCShellInterruptCallback);
 
         AutoJSAPI jsapi;
         jsapi.Init();
         cx = jsapi.cx();
 
+        JS_SetInterruptCallback(cx, XPCShellInterruptCallback);
+
         argc--;
         argv++;
         ProcessArgsForCompartment(cx, argv, argc);
diff --git a/xpcom/base/CycleCollectedJSRuntime.cpp b/xpcom/base/CycleCollectedJSRuntime.cpp
index 03f9eafee8ee..10835eb939ff 100644
--- a/xpcom/base/CycleCollectedJSRuntime.cpp
+++ b/xpcom/base/CycleCollectedJSRuntime.cpp
@@ -547,11 +547,11 @@ CycleCollectedJSRuntime::Initialize(JSRuntime* aParentRuntime,
   SetDOMCallbacks(mJSContext, &DOMcallbacks);
   js::SetScriptEnvironmentPreparer(mJSRuntime, &mEnvironmentPreparer);
 
-  JS::SetGetIncumbentGlobalCallback(mJSRuntime, GetIncumbentGlobalCallback);
+  JS::SetGetIncumbentGlobalCallback(mJSContext, GetIncumbentGlobalCallback);
 
 #ifdef SPIDERMONKEY_PROMISE
-  JS::SetEnqueuePromiseJobCallback(mJSRuntime, EnqueuePromiseJobCallback, this);
-  JS::SetPromiseRejectionTrackerCallback(mJSRuntime, PromiseRejectionTrackerCallback, this);
+  JS::SetEnqueuePromiseJobCallback(mJSContext, EnqueuePromiseJobCallback, this);
+  JS::SetPromiseRejectionTrackerCallback(mJSContext, PromiseRejectionTrackerCallback, this);
   mUncaughtRejections.init(mJSRuntime, JS::GCVector<JSObject*, 0, js::SystemAllocPolicy>(js::SystemAllocPolicy()));
   mConsumedRejections.init(mJSRuntime, JS::GCVector<JSObject*, 0, js::SystemAllocPolicy>(js::SystemAllocPolicy()));
 #endif // SPIDERMONKEY_PROMISE