diff --git a/browser/actors/AboutProtectionsParent.jsm b/browser/actors/AboutProtectionsParent.jsm
index 105aa7278163..ee5b89a0bcfb 100644
--- a/browser/actors/AboutProtectionsParent.jsm
+++ b/browser/actors/AboutProtectionsParent.jsm
@@ -11,6 +11,10 @@ const { XPCOMUtils } = ChromeUtils.importESModule(
 
 const lazy = {};
 
+ChromeUtils.defineESModuleGetters(lazy, {
+  Region: "resource://gre/modules/Region.sys.mjs",
+});
+
 XPCOMUtils.defineLazyModuleGetters(lazy, {
   BrowserUtils: "resource://gre/modules/BrowserUtils.jsm",
   FXA_PWDMGR_HOST: "resource://gre/modules/FxAccountsCommon.js",
@@ -19,7 +23,6 @@ XPCOMUtils.defineLazyModuleGetters(lazy, {
   LoginBreaches: "resource:///modules/LoginBreaches.jsm",
   LoginHelper: "resource://gre/modules/LoginHelper.jsm",
   PrivateBrowsingUtils: "resource://gre/modules/PrivateBrowsingUtils.jsm",
-  Region: "resource://gre/modules/Region.jsm",
 });
 
 XPCOMUtils.defineLazyGetter(lazy, "fxAccounts", () => {
diff --git a/browser/components/doh/DoHConfig.jsm b/browser/components/doh/DoHConfig.jsm
index 62cde6aa57a9..27553bd29887 100644
--- a/browser/components/doh/DoHConfig.jsm
+++ b/browser/components/doh/DoHConfig.jsm
@@ -21,9 +21,12 @@ const { RemoteSettings } = ChromeUtils.import(
 
 const lazy = {};
 
+ChromeUtils.defineESModuleGetters(lazy, {
+  Region: "resource://gre/modules/Region.sys.mjs",
+});
+
 XPCOMUtils.defineLazyModuleGetters(lazy, {
   Preferences: "resource://gre/modules/Preferences.jsm",
-  Region: "resource://gre/modules/Region.jsm",
 });
 
 const kGlobalPrefBranch = "doh-rollout";
diff --git a/browser/components/doh/test/browser/head.js b/browser/components/doh/test/browser/head.js
index 46eeca5472d2..d01ad8f237a9 100644
--- a/browser/components/doh/test/browser/head.js
+++ b/browser/components/doh/test/browser/head.js
@@ -1,12 +1,15 @@
 "use strict";
 
+ChromeUtils.defineESModuleGetters(this, {
+  Region: "resource://gre/modules/Region.sys.mjs",
+});
+
 XPCOMUtils.defineLazyModuleGetters(this, {
   ASRouter: "resource://activity-stream/lib/ASRouter.jsm",
   DoHController: "resource:///modules/DoHController.jsm",
   DoHConfigController: "resource:///modules/DoHConfig.jsm",
   DoHTestUtils: "resource://testing-common/DoHTestUtils.jsm",
   Preferences: "resource://gre/modules/Preferences.jsm",
-  Region: "resource://gre/modules/Region.jsm",
   RegionTestUtils: "resource://testing-common/RegionTestUtils.jsm",
   RemoteSettings: "resource://services-settings/remote-settings.js",
 });
diff --git a/browser/components/newtab/aboutwelcome/AboutWelcomeParent.jsm b/browser/components/newtab/aboutwelcome/AboutWelcomeParent.jsm
index 27ab7bbcd04f..d0bcba825aac 100644
--- a/browser/components/newtab/aboutwelcome/AboutWelcomeParent.jsm
+++ b/browser/components/newtab/aboutwelcome/AboutWelcomeParent.jsm
@@ -12,6 +12,10 @@ const { XPCOMUtils } = ChromeUtils.importESModule(
 
 const lazy = {};
 
+ChromeUtils.defineESModuleGetters(lazy, {
+  Region: "resource://gre/modules/Region.sys.mjs",
+});
+
 XPCOMUtils.defineLazyModuleGetters(lazy, {
   AddonManager: "resource://gre/modules/AddonManager.jsm",
   BrowserUtils: "resource://gre/modules/BrowserUtils.jsm",
@@ -25,7 +29,6 @@ XPCOMUtils.defineLazyModuleGetters(lazy, {
   AboutWelcomeDefaults:
     "resource://activity-stream/aboutwelcome/lib/AboutWelcomeDefaults.jsm",
   PromiseUtils: "resource://gre/modules/PromiseUtils.jsm",
-  Region: "resource://gre/modules/Region.jsm",
   ShellService: "resource:///modules/ShellService.jsm",
   LangPackMatcher: "resource://gre/modules/LangPackMatcher.jsm",
 });
diff --git a/browser/components/newtab/lib/ASRouterTargeting.jsm b/browser/components/newtab/lib/ASRouterTargeting.jsm
index e8a9f779f5dc..c7164898b9d0 100644
--- a/browser/components/newtab/lib/ASRouterTargeting.jsm
+++ b/browser/components/newtab/lib/ASRouterTargeting.jsm
@@ -21,6 +21,10 @@ const { ShellService } = ChromeUtils.import(
 
 const lazy = {};
 
+ChromeUtils.defineESModuleGetters(lazy, {
+  Region: "resource://gre/modules/Region.sys.mjs",
+});
+
 XPCOMUtils.defineLazyModuleGetters(lazy, {
   ASRouterPreferences: "resource://activity-stream/lib/ASRouterPreferences.jsm",
   AddonManager: "resource://gre/modules/AddonManager.jsm",
@@ -29,7 +33,6 @@ XPCOMUtils.defineLazyModuleGetters(lazy, {
   TelemetryEnvironment: "resource://gre/modules/TelemetryEnvironment.jsm",
   AttributionCode: "resource:///modules/AttributionCode.jsm",
   TargetingContext: "resource://messaging-system/targeting/Targeting.jsm",
-  Region: "resource://gre/modules/Region.jsm",
   TelemetrySession: "resource://gre/modules/TelemetrySession.jsm",
   HomePage: "resource:///modules/HomePage.jsm",
   AboutNewTab: "resource:///modules/AboutNewTab.jsm",
diff --git a/browser/components/newtab/lib/ActivityStream.jsm b/browser/components/newtab/lib/ActivityStream.jsm
index 11be3d924c8d..9d3b02cbdb53 100644
--- a/browser/components/newtab/lib/ActivityStream.jsm
+++ b/browser/components/newtab/lib/ActivityStream.jsm
@@ -15,11 +15,9 @@ ChromeUtils.defineModuleGetter(
   "resource://activity-stream/lib/DefaultSites.jsm"
 );
 
-ChromeUtils.defineModuleGetter(
-  lazy,
-  "Region",
-  "resource://gre/modules/Region.jsm"
-);
+ChromeUtils.defineESModuleGetters(lazy, {
+  Region: "resource://gre/modules/Region.sys.mjs",
+});
 
 // NB: Eagerly load modules that will be loaded/constructed/initialized in the
 // common case to avoid the overhead of wrapping and detecting lazy loading.
diff --git a/browser/components/newtab/lib/DiscoveryStreamFeed.jsm b/browser/components/newtab/lib/DiscoveryStreamFeed.jsm
index 34fbb374e431..45fa2b0938a0 100644
--- a/browser/components/newtab/lib/DiscoveryStreamFeed.jsm
+++ b/browser/components/newtab/lib/DiscoveryStreamFeed.jsm
@@ -25,11 +25,9 @@ const { setTimeout, clearTimeout } = ChromeUtils.import(
 const { actionTypes: at, actionCreators: ac } = ChromeUtils.import(
   "resource://activity-stream/common/Actions.jsm"
 );
-ChromeUtils.defineModuleGetter(
-  lazy,
-  "Region",
-  "resource://gre/modules/Region.jsm"
-);
+ChromeUtils.defineESModuleGetters(lazy, {
+  Region: "resource://gre/modules/Region.sys.mjs",
+});
 ChromeUtils.defineModuleGetter(
   lazy,
   "PersistentCache",
diff --git a/browser/components/newtab/lib/PrefsFeed.jsm b/browser/components/newtab/lib/PrefsFeed.jsm
index 96bb87904d35..8b1f893cb136 100644
--- a/browser/components/newtab/lib/PrefsFeed.jsm
+++ b/browser/components/newtab/lib/PrefsFeed.jsm
@@ -18,10 +18,13 @@ const { AppConstants } = ChromeUtils.import(
 
 const lazy = {};
 
+ChromeUtils.defineESModuleGetters(lazy, {
+  Region: "resource://gre/modules/Region.sys.mjs",
+});
+
 XPCOMUtils.defineLazyModuleGetters(lazy, {
   NimbusFeatures: "resource://nimbus/ExperimentAPI.jsm",
   PrivateBrowsingUtils: "resource://gre/modules/PrivateBrowsingUtils.jsm",
-  Region: "resource://gre/modules/Region.jsm",
 });
 
 class PrefsFeed {
diff --git a/browser/components/newtab/lib/TopSitesFeed.jsm b/browser/components/newtab/lib/TopSitesFeed.jsm
index bfff1c80927f..7c78dd41759d 100644
--- a/browser/components/newtab/lib/TopSitesFeed.jsm
+++ b/browser/components/newtab/lib/TopSitesFeed.jsm
@@ -67,11 +67,9 @@ ChromeUtils.defineModuleGetter(
   "RemoteSettings",
   "resource://services-settings/remote-settings.js"
 );
-ChromeUtils.defineModuleGetter(
-  lazy,
-  "Region",
-  "resource://gre/modules/Region.jsm"
-);
+ChromeUtils.defineESModuleGetters(lazy, {
+  Region: "resource://gre/modules/Region.sys.mjs",
+});
 
 XPCOMUtils.defineLazyGetter(lazy, "log", () => {
   const { Logger } = ChromeUtils.import(
diff --git a/browser/components/newtab/test/browser/browser_asrouter_targeting.js b/browser/components/newtab/test/browser/browser_asrouter_targeting.js
index b8f738d42e1f..c36f64c4e09b 100644
--- a/browser/components/newtab/test/browser/browser_asrouter_targeting.js
+++ b/browser/components/newtab/test/browser/browser_asrouter_targeting.js
@@ -32,6 +32,7 @@ ChromeUtils.defineModuleGetter(
 );
 ChromeUtils.defineESModuleGetters(this, {
   PlacesTestUtils: "resource://testing-common/PlacesTestUtils.sys.mjs",
+  Region: "resource://gre/modules/Region.sys.mjs",
 });
 ChromeUtils.defineModuleGetter(
   this,
@@ -41,11 +42,6 @@ ChromeUtils.defineModuleGetter(
 const { AppConstants } = ChromeUtils.import(
   "resource://gre/modules/AppConstants.jsm"
 );
-ChromeUtils.defineModuleGetter(
-  this,
-  "Region",
-  "resource://gre/modules/Region.jsm"
-);
 ChromeUtils.defineModuleGetter(
   this,
   "HomePage",
diff --git a/browser/components/preferences/tests/browser_moreFromMozilla_locales.js b/browser/components/preferences/tests/browser_moreFromMozilla_locales.js
index 00d05125ad7d..7796295cf5d8 100644
--- a/browser/components/preferences/tests/browser_moreFromMozilla_locales.js
+++ b/browser/components/preferences/tests/browser_moreFromMozilla_locales.js
@@ -7,7 +7,9 @@ const { EnterprisePolicyTesting } = ChromeUtils.importESModule(
   "resource://testing-common/EnterprisePolicyTesting.sys.mjs"
 );
 
-let { Region } = ChromeUtils.import("resource://gre/modules/Region.jsm");
+let { Region } = ChromeUtils.importESModule(
+  "resource://gre/modules/Region.sys.mjs"
+);
 
 const initialHomeRegion = Region._home;
 const initialCurrentRegion = Region._current;
diff --git a/browser/components/privatebrowsing/test/browser/browser_privatebrowsing_about_focus_promo.js b/browser/components/privatebrowsing/test/browser/browser_privatebrowsing_about_focus_promo.js
index 4c1e18d75b1f..2400d1a044d1 100644
--- a/browser/components/privatebrowsing/test/browser/browser_privatebrowsing_about_focus_promo.js
+++ b/browser/components/privatebrowsing/test/browser/browser_privatebrowsing_about_focus_promo.js
@@ -1,4 +1,6 @@
-const { Region } = ChromeUtils.import("resource://gre/modules/Region.jsm");
+const { Region } = ChromeUtils.importESModule(
+  "resource://gre/modules/Region.sys.mjs"
+);
 const { ASRouter } = ChromeUtils.import(
   "resource://activity-stream/lib/ASRouter.jsm"
 );
diff --git a/browser/components/protections/test/browser/browser_protections_proxy.js b/browser/components/protections/test/browser/browser_protections_proxy.js
index ea655351b0bc..5db6c05d5c84 100644
--- a/browser/components/protections/test/browser/browser_protections_proxy.js
+++ b/browser/components/protections/test/browser/browser_protections_proxy.js
@@ -4,8 +4,8 @@
 
 "use strict";
 
-XPCOMUtils.defineLazyModuleGetters(this, {
-  Region: "resource://gre/modules/Region.jsm",
+ChromeUtils.defineESModuleGetters(this, {
+  Region: "resource://gre/modules/Region.sys.mjs",
 });
 
 add_setup(async function() {
diff --git a/browser/components/protections/test/browser/browser_protections_vpn.js b/browser/components/protections/test/browser/browser_protections_vpn.js
index 533def85bfbc..7751b5963927 100644
--- a/browser/components/protections/test/browser/browser_protections_vpn.js
+++ b/browser/components/protections/test/browser/browser_protections_vpn.js
@@ -8,7 +8,9 @@ const { AboutProtectionsParent } = ChromeUtils.import(
   "resource:///actors/AboutProtectionsParent.jsm"
 );
 
-let { Region } = ChromeUtils.import("resource://gre/modules/Region.jsm");
+let { Region } = ChromeUtils.importESModule(
+  "resource://gre/modules/Region.sys.mjs"
+);
 
 const initialHomeRegion = Region._home;
 const initialCurrentRegion = Region._current;
diff --git a/browser/components/protections/test/browser/head.js b/browser/components/protections/test/browser/head.js
index 4b3e1630b876..9815869ee5d5 100644
--- a/browser/components/protections/test/browser/head.js
+++ b/browser/components/protections/test/browser/head.js
@@ -12,8 +12,8 @@ const nsLoginInfo = new Components.Constructor(
   "init"
 );
 
-XPCOMUtils.defineLazyModuleGetters(this, {
-  Region: "resource://gre/modules/Region.jsm",
+ChromeUtils.defineESModuleGetters(this, {
+  Region: "resource://gre/modules/Region.sys.mjs",
 });
 
 const { SearchTestUtils } = ChromeUtils.importESModule(
diff --git a/browser/components/urlbar/UrlbarPrefs.sys.mjs b/browser/components/urlbar/UrlbarPrefs.sys.mjs
index 0ba3eb26ca47..a697dabbf6f4 100644
--- a/browser/components/urlbar/UrlbarPrefs.sys.mjs
+++ b/browser/components/urlbar/UrlbarPrefs.sys.mjs
@@ -15,12 +15,12 @@ import { XPCOMUtils } from "resource://gre/modules/XPCOMUtils.sys.mjs";
 const lazy = {};
 
 ChromeUtils.defineESModuleGetters(lazy, {
+  Region: "resource://gre/modules/Region.sys.mjs",
   UrlbarUtils: "resource:///modules/UrlbarUtils.sys.mjs",
 });
 
 XPCOMUtils.defineLazyModuleGetters(lazy, {
   NimbusFeatures: "resource://nimbus/ExperimentAPI.jsm",
-  Region: "resource://gre/modules/Region.jsm",
 });
 
 const PREF_URLBAR_BRANCH = "browser.urlbar.";
diff --git a/browser/components/urlbar/tests/quicksuggest/unit/test_quicksuggest_offlineDefault.js b/browser/components/urlbar/tests/quicksuggest/unit/test_quicksuggest_offlineDefault.js
index 9d702b55531f..a26659e14b3d 100644
--- a/browser/components/urlbar/tests/quicksuggest/unit/test_quicksuggest_offlineDefault.js
+++ b/browser/components/urlbar/tests/quicksuggest/unit/test_quicksuggest_offlineDefault.js
@@ -7,8 +7,8 @@
 
 "use strict";
 
-XPCOMUtils.defineLazyModuleGetters(this, {
-  Region: "resource://gre/modules/Region.jsm",
+ChromeUtils.defineESModuleGetters(this, {
+  Region: "resource://gre/modules/Region.sys.mjs",
 });
 
 // All the prefs that `updateFirefoxSuggestScenario` sets along with the
diff --git a/browser/extensions/formautofill/test/browser/browser_editAddressDialog.js b/browser/extensions/formautofill/test/browser/browser_editAddressDialog.js
index e4229a8fbe83..555de50154de 100644
--- a/browser/extensions/formautofill/test/browser/browser_editAddressDialog.js
+++ b/browser/extensions/formautofill/test/browser/browser_editAddressDialog.js
@@ -4,8 +4,8 @@ const { FormAutofillUtils } = ChromeUtils.import(
   "resource://autofill/FormAutofillUtils.jsm"
 );
 
-XPCOMUtils.defineLazyModuleGetters(this, {
-  Region: "resource://gre/modules/Region.jsm",
+ChromeUtils.defineESModuleGetters(this, {
+  Region: "resource://gre/modules/Region.sys.mjs",
 });
 
 requestLongerTimeout(6);
diff --git a/browser/modules/HomePage.jsm b/browser/modules/HomePage.jsm
index fd2a463c9e8c..f2c77a0300a2 100644
--- a/browser/modules/HomePage.jsm
+++ b/browser/modules/HomePage.jsm
@@ -12,12 +12,15 @@ const { XPCOMUtils } = ChromeUtils.importESModule(
 
 const lazy = {};
 
+ChromeUtils.defineESModuleGetters(lazy, {
+  IgnoreLists: "resource://gre/modules/IgnoreLists.sys.mjs",
+});
+
 XPCOMUtils.defineLazyModuleGetters(lazy, {
   CustomizableUI: "resource:///modules/CustomizableUI.jsm",
   ExtensionParent: "resource://gre/modules/ExtensionParent.jsm",
   ExtensionPreferencesManager:
     "resource://gre/modules/ExtensionPreferencesManager.jsm",
-  IgnoreLists: "resource://gre/modules/IgnoreLists.jsm",
   PrivateBrowsingUtils: "resource://gre/modules/PrivateBrowsingUtils.jsm",
 });
 
diff --git a/browser/modules/PartnerLinkAttribution.jsm b/browser/modules/PartnerLinkAttribution.jsm
index e3092765ad46..b2fd8a7bdb21 100644
--- a/browser/modules/PartnerLinkAttribution.jsm
+++ b/browser/modules/PartnerLinkAttribution.jsm
@@ -15,8 +15,11 @@ const { XPCOMUtils } = ChromeUtils.importESModule(
 
 const lazy = {};
 
+ChromeUtils.defineESModuleGetters(lazy, {
+  Region: "resource://gre/modules/Region.sys.mjs",
+});
+
 XPCOMUtils.defineLazyModuleGetters(lazy, {
-  Region: "resource://gre/modules/Region.jsm",
   PingCentre: "resource:///modules/PingCentre.jsm",
 });
 
diff --git a/browser/modules/test/browser/browser_PartnerLinkAttribution.js b/browser/modules/test/browser/browser_PartnerLinkAttribution.js
index 538b6b1c8c12..f84f040ab59c 100644
--- a/browser/modules/test/browser/browser_PartnerLinkAttribution.js
+++ b/browser/modules/test/browser/browser_PartnerLinkAttribution.js
@@ -17,6 +17,7 @@ const SUGGESTION_ENGINE_NAME =
   "browser_UsageTelemetry usageTelemetrySearchSuggestions.xml";
 
 ChromeUtils.defineESModuleGetters(this, {
+  Region: "resource://gre/modules/Region.sys.mjs",
   SearchTestUtils: "resource://testing-common/SearchTestUtils.sys.mjs",
   UrlbarTestUtils: "resource://testing-common/UrlbarTestUtils.sys.mjs",
 });
@@ -24,7 +25,6 @@ ChromeUtils.defineESModuleGetters(this, {
 XPCOMUtils.defineLazyModuleGetters(this, {
   CustomizableUITestUtils:
     "resource://testing-common/CustomizableUITestUtils.jsm",
-  Region: "resource://gre/modules/Region.jsm",
   HttpServer: "resource://testing-common/httpd.js",
 });
 
diff --git a/toolkit/components/formautofill/FormAutofill.jsm b/toolkit/components/formautofill/FormAutofill.jsm
index bf819e77238b..fab204063e73 100644
--- a/toolkit/components/formautofill/FormAutofill.jsm
+++ b/toolkit/components/formautofill/FormAutofill.jsm
@@ -12,8 +12,8 @@ const { XPCOMUtils } = ChromeUtils.importESModule(
 
 const lazy = {};
 
-XPCOMUtils.defineLazyModuleGetters(lazy, {
-  Region: "resource://gre/modules/Region.jsm",
+ChromeUtils.defineESModuleGetters(lazy, {
+  Region: "resource://gre/modules/Region.sys.mjs",
 });
 
 const ADDRESSES_FIRST_TIME_USE_PREF = "extensions.formautofill.firstTimeUse";
diff --git a/toolkit/components/search/SearchEngine.sys.mjs b/toolkit/components/search/SearchEngine.sys.mjs
index bda05957afa7..dce8612c536f 100644
--- a/toolkit/components/search/SearchEngine.sys.mjs
+++ b/toolkit/components/search/SearchEngine.sys.mjs
@@ -13,11 +13,11 @@ const { AppConstants } = ChromeUtils.import(
 const lazy = {};
 
 ChromeUtils.defineESModuleGetters(lazy, {
+  Region: "resource://gre/modules/Region.sys.mjs",
   SearchUtils: "resource://gre/modules/SearchUtils.sys.mjs",
 });
 
 XPCOMUtils.defineLazyModuleGetters(lazy, {
-  Region: "resource://gre/modules/Region.jsm",
   NimbusFeatures: "resource://nimbus/ExperimentAPI.jsm",
 });
 
diff --git a/toolkit/components/search/SearchService.sys.mjs b/toolkit/components/search/SearchService.sys.mjs
index acd3793fa9f2..2e5baa5f1431 100644
--- a/toolkit/components/search/SearchService.sys.mjs
+++ b/toolkit/components/search/SearchService.sys.mjs
@@ -17,8 +17,10 @@ const lazy = {};
 
 ChromeUtils.defineESModuleGetters(lazy, {
   AddonSearchEngine: "resource://gre/modules/AddonSearchEngine.sys.mjs",
+  IgnoreLists: "resource://gre/modules/IgnoreLists.sys.mjs",
   OpenSearchEngine: "resource://gre/modules/OpenSearchEngine.sys.mjs",
   PolicySearchEngine: "resource://gre/modules/PolicySearchEngine.sys.mjs",
+  Region: "resource://gre/modules/Region.sys.mjs",
   SearchEngine: "resource://gre/modules/SearchEngine.sys.mjs",
   SearchEngineSelector: "resource://gre/modules/SearchEngineSelector.sys.mjs",
   SearchSettings: "resource://gre/modules/SearchSettings.sys.mjs",
@@ -29,8 +31,6 @@ ChromeUtils.defineESModuleGetters(lazy, {
 
 XPCOMUtils.defineLazyModuleGetters(lazy, {
   AddonManager: "resource://gre/modules/AddonManager.jsm",
-  IgnoreLists: "resource://gre/modules/IgnoreLists.jsm",
-  Region: "resource://gre/modules/Region.jsm",
   RemoteSettings: "resource://services-settings/remote-settings.js",
   NimbusFeatures: "resource://nimbus/ExperimentAPI.jsm",
 });
diff --git a/toolkit/components/search/tests/xpcshell/head_search.js b/toolkit/components/search/tests/xpcshell/head_search.js
index e7832e842685..4e5b54e3a83b 100644
--- a/toolkit/components/search/tests/xpcshell/head_search.js
+++ b/toolkit/components/search/tests/xpcshell/head_search.js
@@ -6,6 +6,7 @@ const { XPCOMUtils } = ChromeUtils.importESModule(
 );
 
 ChromeUtils.defineESModuleGetters(this, {
+  Region: "resource://gre/modules/Region.sys.mjs",
   SearchEngineSelector: "resource://gre/modules/SearchEngineSelector.sys.mjs",
   SearchService: "resource://gre/modules/SearchService.sys.mjs",
   SearchSettings: "resource://gre/modules/SearchSettings.sys.mjs",
@@ -17,7 +18,6 @@ XPCOMUtils.defineLazyModuleGetters(this, {
   clearTimeout: "resource://gre/modules/Timer.jsm",
   FileUtils: "resource://gre/modules/FileUtils.jsm",
   PromiseUtils: "resource://gre/modules/PromiseUtils.jsm",
-  Region: "resource://gre/modules/Region.jsm",
   RemoteSettings: "resource://services-settings/remote-settings.js",
   RemoteSettingsClient: "resource://services-settings/RemoteSettingsClient.jsm",
   setTimeout: "resource://gre/modules/Timer.jsm",
diff --git a/toolkit/components/search/tests/xpcshell/searchconfigs/head_searchconfig.js b/toolkit/components/search/tests/xpcshell/searchconfigs/head_searchconfig.js
index 97254e0ccacf..889514ca1186 100644
--- a/toolkit/components/search/tests/xpcshell/searchconfigs/head_searchconfig.js
+++ b/toolkit/components/search/tests/xpcshell/searchconfigs/head_searchconfig.js
@@ -11,6 +11,7 @@ const { AppConstants } = ChromeUtils.import(
 );
 
 ChromeUtils.defineESModuleGetters(this, {
+  Region: "resource://gre/modules/Region.sys.mjs",
   SearchEngine: "resource://gre/modules/SearchEngine.sys.mjs",
   SearchEngineSelector: "resource://gre/modules/SearchEngineSelector.sys.mjs",
   SearchTestUtils: "resource://testing-common/SearchTestUtils.sys.mjs",
@@ -21,7 +22,6 @@ XPCOMUtils.defineLazyModuleGetters(this, {
   AddonManager: "resource://gre/modules/AddonManager.jsm",
   AddonTestUtils: "resource://testing-common/AddonTestUtils.jsm",
   ObjectUtils: "resource://gre/modules/ObjectUtils.jsm",
-  Region: "resource://gre/modules/Region.jsm",
   RemoteSettings: "resource://services-settings/remote-settings.js",
   sinon: "resource://testing-common/Sinon.jsm",
 });
diff --git a/toolkit/components/urlformatter/URLFormatter.jsm b/toolkit/components/urlformatter/URLFormatter.jsm
index 0d7c3fecf81c..036a5a2ec0b2 100644
--- a/toolkit/components/urlformatter/URLFormatter.jsm
+++ b/toolkit/components/urlformatter/URLFormatter.jsm
@@ -31,11 +31,9 @@ ChromeUtils.defineModuleGetter(
   "resource://gre/modules/UpdateUtils.jsm"
 );
 
-ChromeUtils.defineModuleGetter(
-  lazy,
-  "Region",
-  "resource://gre/modules/Region.jsm"
-);
+ChromeUtils.defineESModuleGetters(lazy, {
+  Region: "resource://gre/modules/Region.sys.mjs",
+});
 
 function nsURLFormatterService() {
   XPCOMUtils.defineLazyGetter(this, "ABI", function UFS_ABI() {
diff --git a/toolkit/modules/BrowserUtils.jsm b/toolkit/modules/BrowserUtils.jsm
index e532d6140b5b..7d308df2031d 100644
--- a/toolkit/modules/BrowserUtils.jsm
+++ b/toolkit/modules/BrowserUtils.jsm
@@ -14,11 +14,9 @@ const { XPCOMUtils } = ChromeUtils.importESModule(
   "resource://gre/modules/XPCOMUtils.sys.mjs"
 );
 const lazy = {};
-ChromeUtils.defineModuleGetter(
-  lazy,
-  "Region",
-  "resource://gre/modules/Region.jsm"
-);
+ChromeUtils.defineESModuleGetters(lazy, {
+  Region: "resource://gre/modules/Region.sys.mjs",
+});
 
 XPCOMUtils.defineLazyPreferenceGetter(
   lazy,
diff --git a/toolkit/modules/IgnoreLists.jsm b/toolkit/modules/IgnoreLists.sys.mjs
similarity index 93%
rename from toolkit/modules/IgnoreLists.jsm
rename to toolkit/modules/IgnoreLists.sys.mjs
index 37a60043aebb..8c4f32ee9c71 100644
--- a/toolkit/modules/IgnoreLists.jsm
+++ b/toolkit/modules/IgnoreLists.sys.mjs
@@ -3,9 +3,7 @@
  * You can obtain one at http://mozilla.org/MPL/2.0/. */
 "use strict";
 
-const { XPCOMUtils } = ChromeUtils.importESModule(
-  "resource://gre/modules/XPCOMUtils.sys.mjs"
-);
+import { XPCOMUtils } from "resource://gre/modules/XPCOMUtils.sys.mjs";
 
 const lazy = {};
 
@@ -14,8 +12,6 @@ XPCOMUtils.defineLazyModuleGetters(lazy, {
   RemoteSettingsClient: "resource://services-settings/RemoteSettingsClient.jsm",
 });
 
-var EXPORTED_SYMBOLS = ["IgnoreLists"];
-
 const SETTINGS_IGNORELIST_KEY = "hijack-blocklists";
 
 class IgnoreListsManager {
@@ -95,4 +91,4 @@ class IgnoreListsManager {
   }
 }
 
-const IgnoreLists = new IgnoreListsManager();
+export const IgnoreLists = new IgnoreListsManager();
diff --git a/toolkit/modules/Region.jsm b/toolkit/modules/Region.sys.mjs
similarity index 99%
rename from toolkit/modules/Region.jsm
rename to toolkit/modules/Region.sys.mjs
index add98d55fd09..34a1f82fed4e 100644
--- a/toolkit/modules/Region.jsm
+++ b/toolkit/modules/Region.sys.mjs
@@ -4,11 +4,8 @@
 
 "use strict";
 
-const EXPORTED_SYMBOLS = ["Region"];
+import { XPCOMUtils } from "resource://gre/modules/XPCOMUtils.sys.mjs";
 
-const { XPCOMUtils } = ChromeUtils.importESModule(
-  "resource://gre/modules/XPCOMUtils.sys.mjs"
-);
 const { AppConstants } = ChromeUtils.import(
   "resource://gre/modules/AppConstants.jsm"
 );
@@ -874,7 +871,7 @@ class RegionDetector {
   }
 }
 
-let Region = new RegionDetector();
+export let Region = new RegionDetector();
 Region.init();
 
 // A method that tries to determine if this user is in a US geography.
diff --git a/toolkit/modules/moz.build b/toolkit/modules/moz.build
index 6a2f84272402..1e3fddd22634 100644
--- a/toolkit/modules/moz.build
+++ b/toolkit/modules/moz.build
@@ -177,7 +177,7 @@ EXTRA_JS_MODULES += [
     "Geometry.jsm",
     "HiddenFrame.jsm",
     "Http.jsm",
-    "IgnoreLists.jsm",
+    "IgnoreLists.sys.mjs",
     "IndexedDB.jsm",
     "InlineSpellChecker.jsm",
     "InlineSpellCheckerContent.jsm",
@@ -199,7 +199,7 @@ EXTRA_JS_MODULES += [
     "ProcessType.jsm",
     "ProfileAge.jsm",
     "PromiseUtils.jsm",
-    "Region.jsm",
+    "Region.sys.mjs",
     "RemotePageAccessManager.jsm",
     "ResetProfile.jsm",
     "ResponsivenessMonitor.jsm",
diff --git a/toolkit/modules/tests/xpcshell/test_BrowserUtils.js b/toolkit/modules/tests/xpcshell/test_BrowserUtils.js
index d58d341520c1..561e27fa10c3 100644
--- a/toolkit/modules/tests/xpcshell/test_BrowserUtils.js
+++ b/toolkit/modules/tests/xpcshell/test_BrowserUtils.js
@@ -13,7 +13,9 @@ const { EnterprisePolicyTesting } = ChromeUtils.importESModule(
   "resource://testing-common/EnterprisePolicyTesting.sys.mjs"
 );
 
-const { Region } = ChromeUtils.import("resource://gre/modules/Region.jsm");
+const { Region } = ChromeUtils.importESModule(
+  "resource://gre/modules/Region.sys.mjs"
+);
 
 const { updateAppInfo } = ChromeUtils.import(
   "resource://testing-common/AppInfo.jsm"
diff --git a/toolkit/modules/tests/xpcshell/test_IgnoreList.js b/toolkit/modules/tests/xpcshell/test_IgnoreList.js
index 15d64fc61cbb..0bb9e902233e 100644
--- a/toolkit/modules/tests/xpcshell/test_IgnoreList.js
+++ b/toolkit/modules/tests/xpcshell/test_IgnoreList.js
@@ -3,8 +3,11 @@
 
 "use strict";
 
+ChromeUtils.defineESModuleGetters(this, {
+  IgnoreLists: "resource://gre/modules/IgnoreLists.sys.mjs",
+});
+
 XPCOMUtils.defineLazyModuleGetters(this, {
-  IgnoreLists: "resource://gre/modules/IgnoreLists.jsm",
   PromiseUtils: "resource://gre/modules/PromiseUtils.jsm",
   RemoteSettings: "resource://services-settings/remote-settings.js",
   RemoteSettingsClient: "resource://services-settings/RemoteSettingsClient.jsm",
diff --git a/toolkit/modules/tests/xpcshell/test_Region.js b/toolkit/modules/tests/xpcshell/test_Region.js
index 9234c6ec7332..f3bccadfa376 100644
--- a/toolkit/modules/tests/xpcshell/test_Region.js
+++ b/toolkit/modules/tests/xpcshell/test_Region.js
@@ -4,7 +4,9 @@ const { AppConstants } = ChromeUtils.import(
   "resource://gre/modules/AppConstants.jsm"
 );
 const { HttpServer } = ChromeUtils.import("resource://testing-common/httpd.js");
-const { Region } = ChromeUtils.import("resource://gre/modules/Region.jsm");
+const { Region } = ChromeUtils.importESModule(
+  "resource://gre/modules/Region.sys.mjs"
+);
 const { setTimeout } = ChromeUtils.import("resource://gre/modules/Timer.jsm");
 const { TestUtils } = ChromeUtils.import(
   "resource://testing-common/TestUtils.jsm"
diff --git a/toolkit/modules/tests/xpcshell/test_Region_geocoding.js b/toolkit/modules/tests/xpcshell/test_Region_geocoding.js
index d2bdad059d4d..f44663fd74f0 100644
--- a/toolkit/modules/tests/xpcshell/test_Region_geocoding.js
+++ b/toolkit/modules/tests/xpcshell/test_Region_geocoding.js
@@ -1,6 +1,8 @@
 "use strict";
 
-const { Region } = ChromeUtils.import("resource://gre/modules/Region.jsm");
+const { Region } = ChromeUtils.importESModule(
+  "resource://gre/modules/Region.sys.mjs"
+);
 const { sinon } = ChromeUtils.import("resource://testing-common/Sinon.jsm");
 const { TestUtils } = ChromeUtils.import(
   "resource://testing-common/TestUtils.jsm"