diff --git a/devtools/server/actors/inspector/constants.js b/devtools/server/actors/inspector/constants.js
new file mode 100644
index 000000000000..c253c67b02d5
--- /dev/null
+++ b/devtools/server/actors/inspector/constants.js
@@ -0,0 +1,17 @@
+/* This Source Code Form is subject to the terms of the Mozilla Public
+ * License, v. 2.0. If a copy of the MPL was not distributed with this
+ * file, You can obtain one at http://mozilla.org/MPL/2.0/. */
+
+"use strict";
+
+/**
+ * Any event listener flagged with this symbol will not be considered when
+ * the EventCollector class enumerates listeners for nodes. For example:
+ *
+ *   const someListener = () => {};
+ *   someListener[EXCLUDED_LISTENER] = true;
+ *   eventListenerService.addSystemEventListener(node, "event", someListener);
+ */
+const EXCLUDED_LISTENER = Symbol("event-collector-excluded-listener");
+
+exports.EXCLUDED_LISTENER = EXCLUDED_LISTENER;
diff --git a/devtools/server/actors/inspector/event-collector.js b/devtools/server/actors/inspector/event-collector.js
index e537aa71c80d..3c467dba2ef7 100644
--- a/devtools/server/actors/inspector/event-collector.js
+++ b/devtools/server/actors/inspector/event-collector.js
@@ -17,6 +17,9 @@ const {
 } = require("devtools/shared/layout/utils");
 const Debugger = require("Debugger");
 const ReplayInspector = require("devtools/server/actors/replay/inspector");
+const {
+  EXCLUDED_LISTENER,
+} = require("devtools/server/actors/inspector/constants");
 
 // eslint-disable-next-line
 const JQUERY_LIVE_REGEX = /return typeof \w+.*.event\.triggered[\s\S]*\.event\.(dispatch|handle).*arguments/;
@@ -253,6 +256,7 @@ class MainEventCollector {
    *         An array of unfiltered event listeners or an empty array
    */
   getDOMListeners(node) {
+    let listeners;
     if (typeof node.nodeName !== "undefined" && node.nodeName.toLowerCase() === "html") {
       const winListeners =
         Services.els.getListenerInfoFor(node.ownerGlobal) || [];
@@ -261,9 +265,15 @@ class MainEventCollector {
       const docListeners =
         Services.els.getListenerInfoFor(node.parentNode) || [];
 
-      return [...winListeners, ...docElementListeners, ...docListeners];
+      listeners = [...winListeners, ...docElementListeners, ...docListeners];
+    } else {
+      listeners = Services.els.getListenerInfoFor(node) || [];
     }
-    return Services.els.getListenerInfoFor(node) || [];
+
+    return listeners.filter(listener => {
+      const obj = this.unwrap(listener.listenerObject);
+      return !obj || !obj[EXCLUDED_LISTENER];
+    });
   }
 
   getJQuery(node) {
diff --git a/devtools/server/actors/inspector/moz.build b/devtools/server/actors/inspector/moz.build
index e7e60f1e5d6e..276f7ccd5e8c 100644
--- a/devtools/server/actors/inspector/moz.build
+++ b/devtools/server/actors/inspector/moz.build
@@ -5,6 +5,7 @@
 # file, You can obtain one at http://mozilla.org/MPL/2.0/.
 
 DevToolsModules(
+  'constants.js',
   'css-logic.js',
   'custom-element-watcher.js',
   'document-walker.js',
diff --git a/devtools/server/actors/inspector/walker.js b/devtools/server/actors/inspector/walker.js
index 508981eb1f38..6c1a04749577 100644
--- a/devtools/server/actors/inspector/walker.js
+++ b/devtools/server/actors/inspector/walker.js
@@ -12,6 +12,9 @@ const {walkerSpec} = require("devtools/shared/specs/inspector");
 const {LongStringActor} = require("devtools/server/actors/string");
 const InspectorUtils = require("InspectorUtils");
 const ReplayInspector = require("devtools/server/actors/replay/inspector");
+const {
+  EXCLUDED_LISTENER,
+} = require("devtools/server/actors/inspector/constants");
 
 loader.lazyRequireGetter(this, "getFrameElement", "devtools/shared/layout/utils", true);
 loader.lazyRequireGetter(this, "isAfterPseudoElement", "devtools/shared/layout/utils", true);
@@ -160,9 +163,14 @@ var WalkerActor = protocol.ActorClassWithSpec(walkerSpec, {
     this._retainedOrphans = new Set();
 
     this.onNodeInserted = this.onNodeInserted.bind(this);
+    this.onNodeInserted[EXCLUDED_LISTENER] = true;
     this.onNodeRemoved = this.onNodeRemoved.bind(this);
+    this.onNodeRemoved[EXCLUDED_LISTENER] = true;
     this.onAttributeModified = this.onAttributeModified.bind(this);
+    this.onAttributeModified[EXCLUDED_LISTENER] = true;
     this.onNodeRemovedFromDocument = this.onNodeRemovedFromDocument.bind(this);
+    this.onNodeRemovedFromDocument[EXCLUDED_LISTENER] = true;
+
     this.onMutations = this.onMutations.bind(this);
     this.onSlotchange = this.onSlotchange.bind(this);
     this.onShadowrootattached = this.onShadowrootattached.bind(this);